Barrier patch with soluble film and methods of improving skin appearance
US-2018360698-A1 · Dec 20, 2018 · US
US10561702B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10561702-B2 |
| Application number | US-201616060096-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 9, 2016 |
| Priority date | Dec 16, 2015 |
| Publication date | Feb 18, 2020 |
| Grant date | Feb 18, 2020 |
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The present invention relates to a novel use of proline containing dipeptides for the prevention and/or treatment of skin conditions associated with altered, damaged or malfunctioning sebaceous glands.
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The invention claimed is: 1. A method for the treatment of sebaceous gland disorders selected from the group consisting of sebaceous hyperplasia, hyperseborrhea, acne, seborrheic dermatitis, atopic dermatitis and rosacea, wherein the method comprises topically administering to skin area of a person in need of such treatment an effective amount of a pharmaceutical composition comprising a dipeptidyl peptidase IV (DPP4) inhibitory effective amount of dipeptide diaminobutyroyl benzylamide diacetate. 2. The method according to claim 1 , wherein the amount of the dipeptide diaminobutyroyl benzylamide diacetate in the composition is in a range of 0.5 ppm to 5,000 ppm, based on the total weight of the composition. 3. The method according to claim 1 , which comprises topically applying the composition to the skin area in an amount of 0.1 to 3 mg/cm 2 skin. 4. The method according to claim 1 , wherein the composition is an O/W emulsion comprising an oily phase dispersed in an aqueous phase in the presence of an O/W emulsifier. 5. The method according to claim 4 , wherein the O/W emulsifier is potassium cetyl phosphate. 6. A method for the treatment of oily, shiny, blemished and/or blotchy skin and/or to reduce skin pore size, wherein the method comprises topically administering to skin area of a person in need of such treatment an effective amount of a cosmetic composition comprising a dipeptidyl peptidase IV (DPP4) inhibitory effective amount of dipeptide diaminobutyroyl benzylamide diacetate. 7. The method according to claim 6 , wherein the cosmetic composition is a skin care preparation. 8. The method according to claim 6 , wherein the amount of the dipeptide diaminobutyroyl benzylamide diacetate in the composition is in a range of 0.5 ppm to 5,000 ppm, based on the total weight of the composition. 9. The method according to claim 6 , which comprises topically applying the composition to the skin area in an amount of 0.1 to 3 mg/cm 2 skin. 10. The method according to claim 6 , wherein the composition is an O/W emulsion comprising an oily phase dispersed in an aqueous phase in the presence of an O/W emulsifier. 11. The method according to claim 10 , wherein the O/W emulsifier is potassium cetyl phosphate.
Proteins; Peptides; Derivatives or degradation products thereof · CPC title
Preparations for oily skin · CPC title
Dipeptides · CPC title
Preparations for care of the skin · CPC title
Anti-acne agents · CPC title
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