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US-2024383827-A1 · Nov 21, 2024 · US
MAO inhibitors and their conjugates as therapeutics for the treatment of brain cancer
US10561663B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10561663-B2 |
| Application number | US-201816109201-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 22, 2018 |
| Priority date | Jul 26, 2011 |
| Publication date | Feb 18, 2020 |
| Grant date | Feb 18, 2020 |
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- Title
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Abstract
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A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148-clorgyline, and their salt thereof. The composition and method are particularly effective in reducing the size of glioblastomas that are temozolomide (TMZ) resistant.
First claim
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What is claimed is: 1. A compound comprising a salt of or a carboxylic acid or ester analog thereof. 2. A pharmaceutical composition comprising the compound of claim 1 .
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Classifications
having five-membered rings · CPC title
Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) {; Imines (C—N=C)} · CPC title
Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin · CPC title
- A61K31/5375Primary
1,4-Oxazines, e.g. morpholine · CPC title
having aromatic rings {, e.g. ketamine, nortriptyline (methadone A61K31/137)} · CPC title
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- What does patent US10561663B2 cover?
- A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148-clorgyline, and their salt thereof. The composition and method are particularly effective in…
- Who is the assignee on this patent?
- Univ Southern California
- What technology area does this patent fall under?
- Primary CPC classification A61K31/5375. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).