Hydroxyflavanones as appetite stimulants

Patent metadata

Field	Value
Publication number	US-10561633-B2
Application number	US-201515329062-A
Country	US
Kind code	B2
Filing date	Jul 26, 2015
Priority date	Jul 30, 2014
Publication date	Feb 18, 2020
Grant date	Feb 18, 2020

Abstract

The invention relates to compounds of formula (I) or the salts thereof, said compounds of formula (I) being selected from among the group consisting of homoeriodictyol (1), eriodictyol (2), hesperetin (3) and sterubin (4), for use in the treatment of an ailment which can be alleviated or prevented by influencing the serotonin level and the concentration of free fatty acids in the blood.

First claim

The invention claimed is:

1. A method for reducing serotonin levels in a mammal in need thereof comprising orally administering to the mammal a dose of about 0.03 μg/kg to about 3 mg/kg of a compound selected from the group consisting of:

a salt thereof, and mixtures thereof.

2. The method of claim 1 , wherein the compound is administered as an orally consumable medicament.

3. The method of claim 2 , wherein the orally consumable medicament comprises:
(i) at least one compound selected from the group consisting of:

a salt thereof, and mixtures thereof,

(ii) at least one solid carrier, and
(iii) one or more flavorings,
with the proviso that the sum of components (i), (ii) and (iii), together with any further ingredients, is 100% by weight, based on the total amount of the medicament.

4. The method of claim 1 , wherein countercations of the salts are selected from the group consisting of ammonium, trialkylammonium, sodium, potassium, magnesium, calcium, and mixtures thereof.

5. The method of claim 1 , wherein the compound is administered as an orally consumable foodstuff consumed for nourishment or pleasure comprising:
(i) at least one compound selected from the group consisting of:

a salt thereof, and a mixture thereof,

(ii) at least one solid carrier, and
(iii) one or more flavorings,
with the proviso that the sum of components (i), (ii) and (iii), together with any further ingredients, is 100% by weight, based on the total amount of the foodstuff.

6. The method of claim 1 , wherein the compound is administered as a food supplement comprising:
(i) at least one compound selected from the group consisting of:

a salt thereof, and mixtures thereof,

(ii) at least one solid carrier, and
(iii) one or more flavorings,
with the proviso that the sum of components (i), (ii) and (iii), together with any further ingredients, is 100% by weight, based on the total amount of the food supplement.

7. The method of claim 2 , wherein the medicament is a tablet or capsule.

8. The method of claim 3 , wherein the at least one solid carrier is selected from silicone dioxide, gum Arabic, and a maltodextrin having a DE value in the range of 5 to 20.

9. The method of claim 3 , wherein the at least one solid carrier has a mean particle size of 30 to 300 mm and a residual moisture content of less than or equal to 5% by weight.

10. The method of claim 5 , wherein the at least one solid carrier is selected from silicone dioxide, gum Arabic, and a maltodextrin having a DE value in the range of 5 to 20.

11. The method of claim 5 , wherein the at least one solid carrier has a mean particle size of 30 to 300 μm and a residual moisture content of less than or equal to 5% by weight.

12. The method of claim 5 , wherein the foodstuff further comprises:
(iv) one or more sweeteners.

13. The method of claim 12 , wherein the foodstuff further comprises:
(v) one or more thickeners.

14. The method of claim 5 , wherein the foodstuff is chewing gum comprising a water-insoluble component and a water-soluble component.

Assignees

• Symrise Ag

Inventors

• Somoza Veronika
• Rohm Barbara
• Liszt Kathrin
• Pignitter Marc
• Hochkogler Christina
• Ley Jakob
• Widder Sabine
• Krammer Gerhard

Classifications

• A61P1/14

  Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents · CPC title

• A23L33/10

  using additives (addition of substantially indigestible substances A23L33/21) · CPC title

• A23C23/00

  Other dairy products · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• C07D311/30

  not hydrogenated in the hetero ring, e.g. flavones · CPC title