Quantitative magnetic resonance imaging relaxometry with suppression of blood signal

Patent metadata

Field	Value
Publication number	US-10557906-B2
Application number	US-201715499518-A
Country	US
Kind code	B2
Filing date	Apr 27, 2017
Priority date	Apr 29, 2016
Publication date	Feb 11, 2020
Grant date	Feb 11, 2020

Abstract

Pulse sequences for an MRI apparatus can provide improved quantitative relaxometry in liver and other tissues. Relaxation parameters such as T1rho or T2 (or both at once) can be measured. The pulse sequence can include a magnetization preparation pulse sequence and an acquisition pulse sequence including a fast spin echo (FSE) pulse sequence. Flip angles and echo time for the FSE pulse sequence can be chosen to optimize image quality without affecting the quantification of a relaxation parameter. Additional pulse sequences, e.g., for enhanced blood suppression and/or fat suppression can be incorporated. The acquisition pulse sequence can have a duration that allows data for a single slice image to be acquired during a breath-hold.

First claim

What is claimed is:

1. A method of generating an image using a magnetic resonance imaging (MRI) apparatus, the method comprising:
applying a magnetization reset pulse sequence;
applying a magnetization preparation pulse sequence for quantification of a relaxation parameter, wherein a time between applying the magnetization reset pulse sequence and applying the magnetization preparation pulse sequence corresponds to a T1 recovery period;
applying an acquisition pulse sequence including a fast spin echo (FSE) pulse sequence, the FSE pulse sequence including an excitation pulse and a plurality of refocusing pulses, wherein a delay time between applying the magnetization preparation pulse sequence and applying the acquisition pulse sequence is 2 ms or less;
acquiring data during the acquisition pulse sequence;
generating image data based on the acquired data, wherein in the image data, a blood signal is at least partially suppressed; and
quantifying, based on the image data, the relaxation parameter at each of a plurality of locations within a region of a subject of interest.

2. The method of claim 1 wherein the relaxation parameter is T1rho or T2.

3. The method of claim 1 wherein the magnetization preparation pulse sequence includes a T1rho preparation sequence.

4. The method of claim 1 wherein the magnetization preparation pulse sequence includes a T2 preparation sequence.

5. The method of claim 1 wherein the magnetization preparation pulse sequence includes a T1rho preparation sequence and a T2 preparation sequence, and wherein the data acquired during the acquisition pulse sequence is used to quantify both T1rho and T2.

6. The method of claim 5 further comprising:
computing, based on the quantification of T1rho and T2, a composite parameter R1rho−R2, wherein R1rho=1/T1rho and R2=1/T2.

7. The method of claim 1 further comprising:
during the T1 recovery period, applying a blood suppression pulse sequence.

8. The method of claim 7 wherein the blood suppression pulse sequence is a double inversion recovery (DIR) sequence.

9. The method of claim 7 wherein the blood suppression pulse sequence is a motion-sensitized driven equilibrium (MSDE) sequence applied near the end of the T1 recovery period.

10. The method of claim 7 wherein the blood suppression pulse sequence is a delay alternating with nutation for tailored excitation (DANTE) sequence.

11. The method of claim 1 further comprising:
during the T1 recovery period, applying a fat suppression pulse sequence.

12. The method of claim 11 wherein the fat suppression pulse sequence is a spectral attenuated inversion recovery (SPAIR) sequence.

13. The method of claim 1 further comprising:
during the T1 recovery period, applying a spectral attenuated inversion recovery (SPAIR) sequence for fat suppression; and
after applying the SPAIR sequence, applying a blood suppression sequence.

14. The method of claim 13 wherein the blood suppression sequence is a motion-sensitized driven equilibrium (MSDE) sequence.

15. The method of claim 1 further comprising, during the T1 recovery period:
applying a double inversion recovery (DIR) sequence for blood suppression; and
after applying the DIR sequence, applying a spectral attenuated inversion recovery (SPAIR) sequence for fat suppression.

16. The method of claim 1 further comprising:
selecting a flip angle and an echo time for each of the plurality of refocusing pulses of the FSE pulse sequence.

17. The method of claim 16 wherein the flip angle is selected to be a constant flip angle within a range from 75° to 180°.

18. The method of claim 16 wherein the flip angle is selected to be a variable flip angle that varies within a range from about 70° to about 130°.

19. The method of claim 16 wherein the selected echo time is within a range from about 15 ms to about 35 ms.

20. The method of claim 1 further comprising:
selecting a flip angle for the excitation pulse of the FSE pulse sequence.

21. The method of claim 20 wherein the flip angle is selected to be a 90° angle.

22. The method of claim 20 wherein the flip angle is selected to be a 60° angle.

23. The method of claim 1 wherein the FSE pulse sequence is a single-shot FSE pulse sequence.

24. The method of claim 1 wherein the magnetization preparation pulse sequence includes a T1rho preparation pulse sequence, the method further comprising:
selecting a spin-lock time (TSL) for the T1rho preparation pulse sequence.

25. The method of claim 24 wherein the selected spin-lock time is within a range from 0 to 60 ms.

26. The method of claim 1 wherein the subject of interest comprises a tissue of a patient.

27. The method of claim 26 wherein the tissue comprises liver tissue.

28. The method of claim 1 wherein the MRI apparatus provides a field strength of at least 1.5 T.

29. The method of claim 1 wherein the MRI apparatus provides a field strength of at least 3.0 T.

30. The method of claim 1 wherein quantifying the relaxation parameter includes applying a mono-exponential relaxation model to the image data.

31. The method of claim 1 wherein the acquisition pulse sequence includes a phase compensation sequence prior to the FSE pulse sequence.

32. An MRI system comprising:
an MRI apparatus having a magnet, a gradient coil, and one or more radiofrequency (RF) coils; and
a computer communicably coupled to the Mill apparatus, the computer having a processor, a memory, and a user interface, the processor being configured to:
control the Mill apparatus to apply a magnetization reset pulse sequence;
control the MRI apparatus to apply a magnetization preparation pulse sequence for quantification of a relaxation parameter, wherein a time between applying the magnetization reset pulse sequence and applying the magnetization preparation pulse sequence corresponds to a T1 recovery period;
control the MRI apparatus to apply an acquisition pulse sequence including a fast spin echo (FSE) pulse sequence, the FSE pulse sequence including an excitation pulse and a plurality of refocusing pulses, wherein a delay time between applying the magnetization preparation pulse sequence and applying the acquisition pulse sequence is 2 ms or less;
acquire data from the MRI apparatus during the acquisition pulse sequence;
generate image data based on the acquired data, wherein in the image data, a blood signal is at least partially suppressed; and
quantify, based on the image data, the relaxation parameter at each of a plurality of locations within a region of a subject of interest.

33. The MRI system of claim 32 wherein the relaxation parameter is T1rho or T2.

34. The MRI system of claim 32 wherein the magnetization preparation pulse sequence includes a T1rho preparation sequence.

35. The MRI system of claim 32 wherein the magnetization preparation pulse sequence includes a T2 preparation sequence.

36. The Mill system of claim 32 wherein the magnetization preparation pulse sequence includes a T1rho preparation sequence and a T2 preparation sequence, and wherein the processor is further configured such that the data acquired during the acquisition pulse sequence is used to quantify both T1rho and T2.

37. The MRI sys

Assignees

• Univ Hong Kong Chinese

Inventors

• Chen Weitian
• Wang yi-xiang
• Baiyan Jiang

Classifications

• G01R33/50

  based on the determination of relaxation times {, e.g. T1 measurement by IR sequences; T2 measurement by multiple-echo sequences} · CPC title

• G01R33/543

  Control of the operation of the MR system, e.g. setting of acquisition parameters prior to or during MR data acquisition, dynamic shimming, use of one or more scout images for scan plane prescription (G01R33/546 takes precedence) · CPC title

• G01R33/5607 Primary

  by reducing the NMR signal of a particular spin species, e.g. of a chemical species for fat suppression, or of a moving spin species for black-blood imaging · CPC title

• G01R33/448

  Relaxometry, i.e. quantification of relaxation times or spin density (G01R33/50 takes precedence) · CPC title

• G01R33/5617

  using RF refocusing, e.g. RARE · CPC title