Method and apparatus for determining tissue morphology based on phase angle

Patent metadata

Field	Value
Publication number	US-10555685-B2
Application number	US-201213584368-A
Country	US
Kind code	B2
Filing date	Aug 13, 2012
Priority date	Dec 28, 2007
Publication date	Feb 11, 2020
Grant date	Feb 11, 2020

Abstract

A compensation circuit has a predetermined, known complex impedance and is located in a handle of a catheter or in a distal end of a cable that connects to the catheter. The compensation circuit is probed with a pilot signal produced by a compensation control. The compensation control measures the complex impedance, which is the combination of the circuit's known impedance as well as that of the cable and then determines the difference between the measured and the known complex impedances which represents that which is attributable to the cable, and is used to cancel out such cable-related contributions to complex impedance in other electrical connections in the same cable. In another aspect, an unknown tissue is identified as one of a plurality of possible tissue types such as regular myocardium, scar and fat based on the measured phase angle of the complex impedance of the unknown tissue.

First claim

What is claimed is:

1. A method of determining tissue type and ablating comprising the steps of:
defining a plurality of tissue types to include regular myocardium, scar and fat;
correlating each one of the tissue types with both a respective phase angle value and magnitude value associated with a complex impedance of each of said tissue types to thereby define a first relationship between said regular myocardium tissue type and a high phase angle value and a medium magnitude, a second relationship between said scar tissue type and a low phase angle value and a low magnitude value, and a third relationship between said fat tissue type and a low phase angle value and a high magnitude value, and wherein said high phase angle value is higher than said low phase angle value, and wherein said medium magnitude value is between said high and low magnitude values;
providing a first electrode in contact with tissue where the tissue may be one of said plurality of tissue types including regular myocardium, scar and fat;
providing a second electrode,
measuring a complex impedance at a preselected excitation frequency between the first electrode and the second electrode where the measured complex impedance comprises a magnitude and a phase angle;
selecting one of the first, second, and third relationships based directly on both the measured phase angle value from the measured complex impedance and the measured magnitude value from the measured complex impedance;
identifying, using a tissue type identification logic block implemented on a computer-based controller, one of regular myocardium, scar and fat tissue types based on the selected one of said first, second, and third relationships wherein the tissue type identification logic block produces an output indicative of the identified tissue type; and
applying, using an ablation generator responsive to the output indicative of the identified tissue type, ablation energy to the tissue when the identified tissue type is regular myocardium.

2. The method of claim 1 wherein said step of providing the first electrode includes the substeps of:
selecting a size between Five French (5 Fr) and Ten French (10 Fr) in diameter and 2 to 8 mm in length for the first electrode.

3. The method of claim 1 wherein said step of providing the first electrode includes the substeps of:
introducing the first electrode using a catheter during a cardiac catheter ablation procedure for contact with the tissue.

4. The method of claim 1 wherein said step of measuring the complex impedance includes the substep of:
selecting, the excitation frequency from a range between 20 kHz and 1000 kHz.

5. The method of claim 4 wherein said range is between 50 kHz and 500 kHz.

6. The method of claim 1 wherein said second electrode is a dispersive/indifferent reference electrode, said measured complex impedance reflecting properties of tissue proximate said first electrode.

7. The method of claim 1 wherein said first and second electrodes are each electrodes in contact with the tissue, said measured complex impedance reflecting properties of tissue between the first and second electrodes.

8. An apparatus for determining one of a plurality of tissue types and for ablating, said apparatus comprising;
a source configured to supply an excitation signal at a predetermined frequency to a catheter for application at a first electrode of the catheter;
a measurement circuit configured to measure a complex impedance between said first electrode and a second electrode responsive to said excitation signal being supplied where said measured complex impedance comprises a magnitude and a phase angle; and
a tissue identification logic block configured to identify one of said plurality of tissue types including regular myocardium, scar and fat, said logic block comprising a correlation for each one of the tissue types with both a respective phase angle value and magnitude value associated with a complex impedance of each of said tissue types to thereby define a first relationship between said regular myocardium tissue type and a high phase angle value and a medium magnitude, a second relationship between said scar tissue type and a low phase angle value and a low magnitude value, and a third relationship between said fat tissue type and a low phase angle value and a high magnitude value, and wherein said high phase angle value is higher than said low phase angle value, and wherein said medium magnitude value is between said high and low magnitude values, said logic block being further configured to select one of said first, second, and third relationships based directly on both the measured phase angle value and the measured magnitude value, said logic block being further configured to identify one of regular myocardium, scar and fat tissue types based on said selected one of said first, second, and third relationships; and
an RF ablation generator configured to generate an ablation signal so as to allow ablation of tissue when the tissue identification block identifies the tissue type of the tissue as being regular myocardium.

9. The apparatus of claim 8 wherein a size of said first electrode is between Five French (5 Fr) and Ten French (10 Fr) in diameter and 2 to 8 mm in length.

10. The apparatus of claim 8 wherein said preselected frequency of said excitation signal is between 20 kHz and 1000 kHz.

11. The apparatus of claim 10 wherein said preselected frequency is between 50 kHz and 500 kHz.

12. The apparatus of claim 8 wherein said second electrode is a dispersive/indifferent reference electrode, said measured complex impedance reflecting properties of tissue proximate said first electrode.

13. The apparatus of claim 8 wherein said first and second electrodes are in contact with said tissue, said measured complex impedance reflecting properties of tissue between said first and second electrodes.

14. A method for determining a type of a tissue that may be one of a plurality of types and for ablating, comprising the steps of:
(A) defining a plurality of tissue types to include regular myocardium, scar and fat;
(B) correlating each one of the tissue types with both a respective phase angle value and magnitude value associated with a complex impedance of each of said tissue types to thereby define a first relationship between said regular myocardium tissue type and a high phase angle value and a medium magnitude, a second relationship between said scar tissue type and a low phase angle value and a low magnitude value, and a third relationship between said fat tissue type and a low phase angle value and a high magnitude value, and wherein said high phase angle value is higher than said low phase angle value, and wherein said medium magnitude value is between said high and low magnitude values;
(C) measuring a phase angle component and a magnitude component of a complex impedance of the tissue by applying an excitation signal having a frequency between 20 kHz and 100 kHz to an electrode that is in contact with the tissue and measuring the response signal induced thereby to determine the measured phase angle value and magnitude value;
(D) selecting one of the first, second, and third relationships based directly on both the measured phase angle value and the measured magnitude value;
(E) identifying, using a tissue type identification logic block implemented on a computer-based controller, one of the regular myocardium tissue type, scar tissue type, and fat tissue type based on the selected one of said first, second, and third relationships wherein the tissue type identification logic block produces an output indicative of the identified

Assignees

• Cao Hong
• Paul Saurav
• St Jude Medical Atrial Fibrillation Div Inc

Inventors

• Cao Hong
• Paul Saurav

Classifications

• A61B5/053 Primary

  Measuring electrical impedance or conductance of a portion of the body · CPC title