Two-carbon linked artemisinin-derived trioxane dimers
US-2015361088-A1 · Dec 17, 2015 · US
US10550128B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10550128-B2 |
| Application number | US-201916291332-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 4, 2019 |
| Priority date | Dec 19, 2014 |
| Publication date | Feb 4, 2020 |
| Grant date | Feb 4, 2020 |
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A hydrogenated Diels-Alder adduct of the formula (III) a hydrogenated Diels-Alder adduct of the formula (IV) and a lactone compound of formula (V) are disclosed and described.
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The invention claimed is: 1. A hydrogenated Diels-Alder adduct of the formula (IV) wherein X and Y are different and independently selected from the group consisting of —CHO, —CH 2 OR 3 and —COOR 4 , wherein R 3 is selected from the group consisting of hydrogen, alkyl, aryl, alkaryl, aralkyl, alkylcarbonyl and arylcarbonyl, and wherein R 4 is selected from the group consisting of hydrogen, alkyl and aryl. 2. A lactone compound of formula (V) wherein Y is hydrogen and X is selected from the group consisting of alkyl, aralkyl, —CHO, —CH 2 OR 3 , —CH(OR 4 )(OR 5 ), —COOR 6 , wherein R 3 , R 4 and R 5 are the same or different and are independently selected from the group consisting of hydrogen, alkyl, aryl, alkaryl, aralkyl, alkylcarbonyl and arylcarbonyl, or wherein R 4 and R 5 together form an alkylene group, and wherein R 6 is selected from the group consisting of hydrogen, alkyl and aryl. 3. The lactone compound according to claim 2 , wherein Y is hydrogen and X is selected from the group consisting of alkyl, aralkyl, —CHO, or —CH 2 OR 3 , wherein R 3 is selected from the group consisting of hydrogen, alkyl and aryl.
with one oxygen atom directly attached in position 1 or 3 · CPC title
with two oxygen atoms directly attached in positions 1 and 3 · CPC title
Ortho-condensed systems · CPC title
Bridged systems · CPC title
of cyclic compounds with ring-splitting · CPC title
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