Separating carboxylic acids

Patent metadata

Field	Value
Publication number	US-10550064-B2
Application number	US-201615769568-A
Country	US
Kind code	B2
Filing date	Nov 1, 2016
Priority date	Nov 6, 2015
Publication date	Feb 4, 2020
Grant date	Feb 4, 2020

Abstract

A process of separating carboxylic acids comprising two steps. The first step is to provide an aqueous solution comprising (i) one or more mono-carboxylic acids, (ii) one or more di-carboxylic acids, and (iii) one or more tri-carboxylic acids. The second step is to pass the aqueous solution through a collection of resin particles, where the resin particles comprise covalently bound quaternary ammonium groups, and wherein the collection of resin particles has uniformity coefficient of 1.5 or less.

First claim

The invention claimed is:

1. A process of separating carboxylic acids from each other and from monosaccharides comprising
(a) providing an aqueous solution comprising
(i) one or more mono-carboxylic acids,
(ii) one or more di-carboxylic acids,
(iii) one or more tri-carboxylic acids, and
(iv) one or more monosaccharides, and

(b) passing the aqueous solution through a collection of gel resin particles, where the gel resin particles comprise at least 90 wt % polymerized units of styrene, from 1 to 10 wt % polymerized units of multivinyl monomer and covalently bound quaternary ammonium groups, wherein the collection of gel resin particles has uniformity coefficient of 1.3 or less and volume-average diameter of 500 μm or less, and wherein the aqueous solution is passed through the gel resin particles in a vessel in one of two ways: (1) a fixed amount of the aqueous solution is added to the vessel, followed by adding continuously an eluent fluid, with collection and analysis of fluid exiting the vessel, or (2) the vessel is one of a plurality of vessels operated in a simulated moving bed method.

2. The process of claim 1 , wherein the aqueous solution comprises glucose.

3. The process of claim 2 , wherein the collection of gel resin particles has volume-average diameter of 400 μm or less.

4. The process of claim 3 , wherein the collection of gel resin particles comprises anions, and wherein 75 mole % or more of the anions are sulfate.

5. The process of claim 4 , wherein the eluent is a solution of one or more inorganic acids in water, wherein total concentration of inorganic acid is 5 g/L or less, and wherein total concentration of inorganic acid is 0.1 g/L or more.

6. The process of claim 5 , wherein each of said one or more mono-carboxylic acids has no more than 6 carbon atoms, wherein each of said one or more di-carboxylic acids has no more than 8 carbon atoms, and wherein each of said one or more tri-carboxylic acids has no more than 8 carbon atoms.

Assignees

• Rohm & Haas
• Dow Global Technologies Llc

Inventors

• Martin Collin H
• Pease Stephen
• Gisch Daryl J
• Baudouin Stanislas

Classifications

• C07H3/00

  Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms (preparation by hydrolysis of di-or polysaccharides C13; separation or purification of sucrose, glucose, fructose, lactose or maltose C13) · CPC title

• C07H3/02

  Monosaccharides · CPC title

• B01D15/34

  Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation · CPC title

• B01J20/26

  Synthetic macromolecular compounds · CPC title

• B01J20/28004

  Sorbent size or size distribution, e.g. particle size · CPC title