Cyclopropylamines as lsd1 inhibitors
US-2015225375-A1 · Aug 13, 2015 · US
Treatment of relapsed and/or refractory solid tumors and non-Hodgkin's lymphomas
US10548896B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10548896-B2 |
| Application number | US-201916387318-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 17, 2019 |
| Priority date | Aug 10, 2016 |
| Publication date | Feb 4, 2020 |
| Grant date | Feb 4, 2020 |
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- Title
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Abstract
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Methods are provided for the treatment of relapsed and/or refractory solid tumors (including neuroendocrine carcinomas (NEC)) and non-Hodgkin's lymphomas (NHLs) and the like, using substituted heterocyclic derivative compounds and pharmaceutical compositions comprising compounds useful for the inhibition of lysine specific demethylase-1 (LSD-1).
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for the treatment of gastric neuroendocrine carcinoma comprising the administration to a patient in need thereof an effective amount of a compound having the structure of: or a pharmaceutically acceptable salt thereof. 2. The method of claim 1 , wherein the administration is affected by oral administration. 3. The method of claim 1 , wherein the effective amount of the compound comprises about 1.5 mg/kg to about 10 mg/kg. 4. The method of claim 1 , wherein the compound is in the form of a tablet, pill, sachet, or capsule of hard or soft gelatin. 5. The method of claim 1 , wherein the compound is in the form of a capsule containing the compound at dosage strengths comprising about 0.50 mg, 0.75 mg, or 2.00 mg.
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having an oxo group in position 17, e.g. androsterone · CPC title
having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel · CPC title
Compounds containing methylenedioxyphenyl groups, e.g. sesamin · CPC title
Antineoplastic agents · CPC title
Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00 · CPC title
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Frequently asked questions
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- What does patent US10548896B2 cover?
- Methods are provided for the treatment of relapsed and/or refractory solid tumors (including neuroendocrine carcinomas (NEC)) and non-Hodgkin's lymphomas (NHLs) and the like, using substituted heterocyclic derivative compounds and pharmaceutical compositions comprising compounds useful for the inhibition of lysine specific demethylase-1 (LSD-1).
- Who is the assignee on this patent?
- Celgene Quanticel Res Inc
- What technology area does this patent fall under?
- Primary CPC classification A61K31/513. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 04 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).