Process to prepare treprostinil, the active ingredient in remodulin®
US-9593066-B2 · Mar 14, 2017 · US
Process to prepare treprostinil, the active ingredient in Remodulin®
US10548863B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10548863-B2 |
| Application number | US-201715423021-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 2, 2017 |
| Priority date | Dec 17, 2007 |
| Publication date | Feb 4, 2020 |
| Grant date | Feb 4, 2020 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of preparing a pharmaceutical product from a pharmaceutical batch that can be stored as a stable compound at ambient temperature and that is prepared by a method comprising (a) alkylating a benzindene triol, (b) hydrolyzing the product of step (a) to form a solution comprising treprostinil, (c) contacting the solution comprising treprostinil from step (b) with a base to form a salt of treprostinil, wherein purity is at least 99.5% as determined by HPLC area under the curve analysis, comprising storing the pharmaceutical batch at ambient temperature and preparing a pharmaceutical product from the pharmaceutical batch after storage. 2. A method as claimed in claim 1 , wherein the salt of treprostinil is a diethanolamine salt. 3. A method of preparing a pharmaceutical batch of a salt of treprostinil that can be stored as a stable compound at ambient temperature and that is prepared by a method comprising (a) alkylating a benzindene triol, (b) hydrolyzing the product of step (a) to form a solution comprising treprostinil, (c) contacting the solution comprising treprostinil from step (b) with a base to form a salt of treprostinil, wherein purity of the batch is at least 99.5% as determined by HPLC area under the curve analysis, comprising (a) alkylating a benzindene triol, (b) hydrolyzing the product of step (a) to form a solution comprising treprostinil, (c) contacting the solution comprising treprostinil from step (b) with a base to form a pharmaceutical batch of a salt of treprostinil and d) storing the pharmaceutical batch at ambient temperature. 4. A method as claimed in claim 3 , wherein the salt of treprostinil is a diethanolamine salt.
Assignees
Inventors
Classifications
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US10548863B2 cover?
- This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
- Who is the assignee on this patent?
- United Therapeutics Corp
- What technology area does this patent fall under?
- Primary CPC classification C07C51/412. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 04 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).