Anti-migration micropatterned stent coating

Patent metadata

Field	Value
Publication number	US-10548708-B2
Application number	US-201615355529-A
Country	US
Kind code	B2
Filing date	Nov 18, 2016
Priority date	Apr 6, 2012
Publication date	Feb 4, 2020
Grant date	Feb 4, 2020

Abstract

An endoprosthesis has an expanded state and a contracted state, the endoprosthesis includes a stent having an inner surface defining a lumen, having an outer surface, and defining a plurality of apertures through the outer surface, wherein the apertures are arranged in a micropattern; and a coating (e.g., polymeric coating) attached to the outer surface of the stent. The coating includes a base and a tissue engagement portion including a second surface facing outwardly from the stent, the tissue engagement portion including a structure that defines a plurality of holes extending inwardly from the second surface toward the base. The holes are arranged in a micropattern. When the endoprosthesis is expanded to the expanded state in a lumen defined by a vessel wall, the structure applies a force that may reduce stent migration by creating an interlock between the vessel wall and the endoprosthesis.

First claim

The invention claimed is:

1. An endoprosthesis having an expanded state and an unexpanded state, the endoprosthesis comprising:
a stent, wherein the stent has an inner surface defining a lumen, an outer surface, a first end, a second end, and a stent thickness defined between the inner surface and the outer surface, wherein the stent defines a plurality of apertures extending through the stent thickness; and
a polymeric coating surrounding the stent and covering at least some of the apertures, the polymeric coating including a surface facing outwardly from the stent, the polymeric coating including a structure that defines a plurality of openings in the surface defining a plurality of holes extending inwardly from the surface toward the stent, the holes configured to allow tissue ingrowth from the surface into the holes upon initial implantation of the endoprosthesis in a body lumen, wherein the holes are arranged in a micropattern, wherein the surface extends continuously around an entire perimeter of each of the plurality of holes.

2. The endoprosthesis of claim 1 , wherein the polymeric coating and the stent are coterminous.

3. The endoprosthesis of claim 1 , wherein at least some of the plurality of holes extend entirely through the polymeric coating.

4. The endoprosthesis of claim 1 , where at least some of the plurality of holes are blind holes.

5. The endoprosthesis of claim 1 , wherein the polymeric coating includes a base attached to the outer surface of the stent.

6. The endoprosthesis of claim 1 , wherein the plurality of holes have a diameter and a height, wherein a ratio of the height to the diameter is between 1 to 1.3.

7. The endoprosthesis of claim 1 , wherein the plurality of holes have a diameter and a spacing between adjacent holes, wherein a ratio of the spacing to the diameter is between 1.01 to 2.0.

8. The endoprosthesis of claim 1 , wherein the plurality of holes are arranged in a rectangular array.

9. The endoprosthesis of claim 1 , wherein the shape of the plurality of holes is selected from the group consisting of a cylinder, a rectangular prism, a prism with a polygonal base, a sphere, and an ellipsoid.

10. The endoprosthesis of claim 1 , wherein the polymeric coating is a polymeric material selected from the group consisting of hydrogels and silicones.

11. The endoprosthesis of claim 1 , wherein the polymeric coating at least partially covers the inner surface of the stent.

12. The endoprosthesis of claim 1 , wherein the polymeric coating further comprises a plurality of micropillars extending outwardly from the surface.

13. The endoprosthesis of claim 1 , wherein each of the plurality of holes has a side surface extending around the entire perimeter of the hole, the side surface extending from the outwardly facing surface of the coating to a base of the hole.

Assignees

• Boston Scient Scimed Inc

Inventors

• Bertolino William
• Firstenberg Laura Elizabeth
• Mcleod Claire M
• Lai Andrea
• Lam Sandra
• Taylor Shannon

Classifications

• B29C39/026

  characterised by the shape of the surface · CPC title

• B29L2016/00

  Articles with corrugations or pleats (B29L2023/18, {B29L2024/003} take precedence) · CPC title

• A61F2/04 Primary

  Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts (A61F2/18, A61F2/20 take precedence; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95) · CPC title

• A61F2002/8483

  Barbs · CPC title

• B29C33/424

  Moulding surfaces provided with means for marking or patterning (for injection moulding B29C45/372) · CPC title