Oils having antibacterial activity

Patent metadata

Field	Value
Publication number	US-10544085-B2
Application number	US-201815919395-A
Country	US
Kind code	B2
Filing date	Mar 13, 2018
Priority date	Mar 20, 2014
Publication date	Jan 28, 2020
Grant date	Jan 28, 2020

Abstract

Compounds, called liamocins from Aureobasidium pullulans , having the general structure in Formula 1 are disclosed.

where R 1 is either COCH 3 or H; and R 2 is between two to ten O-linked 3,5-dihydroxydecanoate; and R 3 can be a polyol (e.g., L- or D-glycerol, L- or D-threitol, L- or D-erythritol, L- or D-arabitol, L- or D-xylitol, L- or D-lyxitol, L- or D-ribitol, L- or D-allitol, L- or D-altritol, L- or D-mannitol, L- or D-iditol, L- or D-gulitol, L- or D-glucitol (also called sorbitol), L- or D-galactitol (also called dulcitol), and L- or D-talitol), 2-amino-D-mannitol, 2N-acetylamino-D-mannitol, L-rhamnitol, or D-fucitol; except when R 3 is D-mannitol, R 2 is not 2 nor 3 O-linked 3,5-dihydroxydecanoate chains. These liamocins described above in addition to D-mannitol liamocin A1, D-mannitol liamocin A2, D-mannitol liamocin B1, and D-mannitol liamocin B2, alone or in combination with each other, can be used to kill certain bacteria and to treat certain bacterial infections.

First claim

The invention claimed is:

1. A method of preventing a disease caused by S. agalactiae, S. infantarius, S. mitis, S. mutans, S. pneumonia, S. salivarius, S. suis , or S. uberis in an animal susceptible to said disease comprising administering an effective amount of a composition to prevent the growth of said S. agalactiae, S. infantarius, S. mitis, S. mutans, S. pneumonia, S. salivarius, S. suis , or S. uberis in or on said animal, wherein said composition comprises one or more of the compounds of Formula 1, optionally a carrier, and optionally a diluent; and wherein said Formula 1 is

where R 1 is, independently, either COCH 3 or H; and R 2 is, independently, between two to ten O-linked 3,5-dihydroxydecanoate; and R 3 is, independently, one of the following: L- or D-glycerol, L- or D-threitol, L- or D-erythritol, L- or D-arabitol, L- or D-xylitol, L- or D-lyxitol, L- or D-ribitol, L- or D-allitol, L- or D-altritol, L- or D-mannitol, L- or D-iditol, L- or D-gulitol, L- or D-glucitol, L- or D-galactitol, L- or D-talitol, 2-amino-D-mannitol, 2N-acetylamino-D-mannitol, L-rhamnitol, or D-fucitol; and a combination thereof.

2. The method of claim 1 , wherein said compound of Formula 1 is selected from the group comprising L-mannitol liamocin A1, L-mannitol liamocin A2, L-mannitol liamocin B1, L-mannitol liamocin B2, D-mannitol liamocin A1, D-mannitol liamocin A2, D-mannitol liamocin B1, D-mannitol liamocin B2, L-arabitol liamocin A1, L-arabitol liamocin A2, L-arabitol liamocin B1, L-arabitol liamocin B2, D-arabitol liamocin A1, D-arabitol liamocin A2, D-arabitol liamocin B1, D-arabitol liamocin B2, L-threitol liamocin A1, L-threitol liamocin A2, L-threitol liamocin B1, L-threitol liamocin B2, D-threitol liamocin A1, D-threitol liamocin A2, D-threitol liamocin B1, D-threitol liamocin B2, L-glycerol liamocin A1, L-glycerol liamocin A2, L-glycerol liamocin B1, L-glycerol liamocin B2, D-glycerol liamocin A1, D-glycerol liamocin A2, D-glycerol liamocin B1, and D-glycerol liamocin B2.

3. The method of claim 1 , wherein said administering said composition occurs via topical administration, oral administration, or parenteral administration to said animal.

4. The method of claim 1 , wherein said animal is selected from the group consisting of a mammal, a bird, a fish, an amphibian, and a reptile.

Assignees

• Us Agriculture

Inventors

• Bischoff Kenneth M
• Leathers Timothy D
• Price Neil P
• Manitchotpisit Pennapa

Classifications

• A61P31/12

  Antivirals · CPC title

• C07C69/003

  Esters of saturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom · CPC title

• C12P7/62

  Carboxylic acid esters · CPC title

• C07C69/33

  esterified with hydroxy compounds having more than three hydroxy groups (esters of sugars C07H) · CPC title

• C07C69/675 Primary

  of saturated hydroxy-carboxylic acids · CPC title