Compositions containing zinc salts and isothiocyanates for reduction of oral volatile sulfur compounds (VSCs)

Patent metadata

Field	Value
Publication number	US-10543155-B2
Application number	US-201214234517-A
Country	US
Kind code	B2
Filing date	Jul 10, 2012
Priority date	Jul 26, 2011
Publication date	Jan 28, 2020
Grant date	Jan 28, 2020

Abstract

Combinations of a zinc salt and an isothiocyanate are provided, and more particularly to a consumer acceptable oral composition containing such combination which is effective in the reduction of volatile sulfur compounds (VSCs).

First claim

What is claimed is:

1. An oral composition comprising 0.001 to 1 wt. % of a zinc salt selected from the group consisting of zinc lactate and zinc gluconate, and 0.001 to 1 wt. % allyl isothiocyanate to reduce volatile sulfur compounds in the oral cavity, wherein the ratio of the zinc salt and the allyl isothiocyanate in the oral composition is from about 1:10 to about 20:1 by weight, and wherein the oral composition is a chewing gum or a chewy candy.

2. An oral composition effective in reducing hydrogen sulfide (H 2 S), methyl mercaptan (CH 3 SH) and combinations thereof comprising a combination of from about 0.002 to about 2% by weight of zinc lactate and from about 0.001 to about 5% by weight of allyl isothiocyanate in a ratio of about 1:10 to about 20:1 by weight, wherein the oral composition is a chewing gum or a chewy candy.

3. The composition of claim 2 wherein the oral composition further comprises an isothiocyanate selected from the group consisting of phenethyl isothiocyanate (PEITC), benzyl isothiocyanate (BITC) and combinations thereof.

4. A composition of claim 2 wherein the oral composition is uncoated.

5. A method of reducing volatile sulfur compounds selected from group consisting of hydrogen sulfide (H 2 S), methyl mercaptan (CH 3 SH), or combinations thereof in the oral cavity, the method comprising consuming or masticating an oral composition having an effective amount of a combination of an organic zinc salt selected from the group consisting of zinc lactate and zinc gluconate and allyl isothiocyanate, wherein the ratio of the organic zinc salt and the allyl isothiocyanate in the oral composition is from about 1:1 to about 20:1 by weight, and wherein the oral composition is a chewing gum or a chewy candy.

6. The method of claim 5 wherein the combination of zinc lactate and allyl isothiocyanate compounds effectively reduce volatile sulfur compounds more than when employed individually.

7. The method of claim 5 in which the oral composition contains an effective amount of the zinc lactate of about 0.002 to about 2% by weight and allyl isothiocyanate of 0.001 to about 5% by weight.

8. The oral composition of claim 1 , in which the oral composition contains an effective amount of the zinc salt of about 0.01 to about 0.25 wt. %.

9. The oral composition of claim 1 , wherein the combined amount of zinc salt and allyl isothiocyanate is less than 0.50% by weight.

Assignees

• Tian Minmin
• Hanley Bryan
• Dodds Michael
• Wrigley W M Jun Co

Inventors

• Tian Minmin
• Hanley Bryan
• Dodds Michael

Classifications

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title

• A61K31/26

  Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters · CPC title

• A23K20/30

  Oligoelements · CPC title

• A61K8/361

  Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof · CPC title

• A61K9/0058

  Chewing gums (non-medicinal aspects, preparing chewing gum A23G4/00; chewing gum for care of the teeth or oral cavity, e.g. with breath freshener A61Q11/00) · CPC title