Combined brachytherapy and electrochemotherapy catheters

Patent metadata

Field	Value
Publication number	US-10537748-B2
Application number	US-201314416451-A
Country	US
Kind code	B2
Filing date	Jul 23, 2013
Priority date	Jul 23, 2012
Publication date	Jan 21, 2020
Grant date	Jan 21, 2020

Abstract

A medical device for multiple treatment therapies includes a hollow tube (102) having a first end portion with an electrode (104) disposed at the first end portion and an insulator (108) configured over a length of the tube such that conductive materials of the tube, except for the electrode, are electrically isolated from an exterior surface the tube. A conductive connection (127) is configured to electrically couple to the electrode to provide a voltage thereto. A selectively closeable valve (106) is configured to dispense a medical fluid from the tube.

First claim

The invention claimed is:

1. A medical device for multiple treatment therapies, comprising:
a hollow tube having a first end portion which comprises an electrode and an insulator configured over a length of the tube such that conductive materials of the tube except for the electrode are electrically isolated from an exterior surface of the tube;
a conductive connection configured to electrically couple to the electrode to provide a voltage thereto, said conductive connection configured to be releasably inserted into the hollow tube while the hollow tube is positioned at an internal treatment site, wherein the conductive connection is configured to contact the electrode and electrically couple to the electrode while the hollow tube is positioned at the internal treatment site; and
a selectively closeable valve configured to dispense a medical fluid from the tube.

2. The medical device as recited in claim 1 , wherein at least one of (i) the electrode includes a conductive tube covered by the insulator except at the end portion to form a conductive tip, or (ii) the electrode includes a conductive coating or foil formed over a dielectric tube and covered by the insulator except at the end portion to form a conductive tip.

3. The medical device as recited in claim 1 , wherein the electrode includes a conductive tip mounted on the end portion of the tube and the conductive connection includes a wire connected to the tip.

4. The medical device as recited in claim 3 , wherein the tip includes an internal spring contact to provide a releasable connection with the wire.

5. The medical device as recited in claim 4 , wherein the internal spring contact engages a plug on a distal end of the wire.

6. The medical device as recited in claim 3 , wherein the wire includes a spring connector at a distal end to provide a releasable connection with the tip.

7. The medical device as recited in claim 3 , wherein the tip includes an internal thread and the wire includes a threaded portion to engage the internal thread to provide a releasable connection with the tip.

8. The medical device as recited in claim 1 , wherein the conductive connection includes a segmented wire disposed within an elastic sheath such that drawing the elastic sheath causes segments of the segmented wire to separate and releasing the elastic sheath causes the segments to reconnect.

9. The medical device as recited in claim 1 , wherein the electrode includes a conductive tip configured to engage a stopper ring formed at the end portion of the tube, the stopper ring and the tip forming the selectively closeable valve and the conductive connection including a wire connected to the tip.

10. The medical device as recited in claim 1 , wherein the hollow tube includes a second electrode separated from the electrode disposed at the first end portion, the second electrode being connected to a second conductive connection configured to electrically couple to the second electrode to provide a voltage to the second electrode.

11. The medical device as recited in claim 1 , wherein the electrode includes a plurality of wires extending from the end portion, and wherein the plurality of wires are divided to form a plurality of electrodes.

12. The medical device as recited in claim 1 , wherein the selectively closeable valve includes at least one opening in the medical device.

13. The medical device as recited in claim 1 , wherein the medical device is configured to provide combined tumor treatment using two or more of: radio frequency ablation, brachytherapy, chemotherapy and electrochemotherapy.

14. An instrument for combined tumor treatment via brachytherapy and electrochemotherapy, comprising:
a hollow tube configured for insertion of radioactive brachytherapy sources in a target volume, the hollow tube including a first end portion having at least one conductor disposed at the first end portion and an insulator configured over a length of the tube such that conductive materials of the tube, except for the at least one conductor, are electrically isolated from an exterior surface the tube,
a conductive connection configured to electrically couple to the at least one conductor to provide a voltage to the at least one conductor to provide an electric field for electrochemotherapy, said conductive connection configured to be releasably inserted into the hollow tube while the hollow tube is positioned at an internal treatment site, wherein the conductive connection is configured to contact the electrode and electrically couple to the electrode while the hollow tube is positioned at the internal treatment site; and
a selectively closeable valve configured to dispense a medical fluid from the tube to the target volume during the electrochemotherapy to provide increased uptake in tissue due to electroporation.

15. A method for combining treatment modes in an interventional therapy procedure, comprising:
providing a medical device including a hollow tube having a first end portion having at least one conductor disposed at the first end portion and an insulator configured over a length of the tube such that conductive materials of the tube, except for the at least one conductor, are electrically isolated from an exterior surface the tube, a conductive connection configured to electrically couple to the at least one conductor to provide a voltage to an electrode, said conductive connection configured to be releasably inserted into the hollow tube while the hollow tube is positioned at an internal treatment site, wherein the conductive connection is configured to contact the electrode and electrically couple to the electrode while the hollow tube is positioned at the internal treatment site, and a selectively closeable valve configured to dispense a medical fluid from the tube;
positioning the medical device at a first position at or in a target volume in accordance with a plan; performing a first treatment mode using the medical device at the first position to treat the target volume; and
performing a second treatment mode which is different from the first treatment mode using the medical device at the first position to treat the target volume.

Assignees

• Koninklijke Philips Nv

Inventors

• Amthor Thomas Erik
• Krueger Sascha
• Weiss Steffen
• Uhlemann Falk

Classifications

• A61B2018/00613

  Irreversible electroporation · CPC title

• A61B2018/1472

  for use with liquid electrolyte, e.g. virtual electrodes · CPC title

• A61N1/205

  for promoting a biological process · CPC title

• A61N5/1002

  Intraluminal radiation therapy · CPC title

• A61N5/1027

  Interstitial radiation therapy · CPC title