Delivery system

Patent metadata

Field	Value
Publication number	US-10537689-B2
Application number	US-201816158808-A
Country	US
Kind code	B2
Filing date	Oct 12, 2018
Priority date	Mar 7, 2011
Publication date	Jan 21, 2020
Grant date	Jan 21, 2020

Abstract

Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.

First claim

That which is claimed is:

1. A delivery system for forming skin tissue on a patient bodily surface, said delivery system comprising:
(a) an optical detector configured to detect data to create a map of said patient bodily surface, which optical detector further comprises a depth detector, operatively associated with said optical detector, to account for movement of said patient during said detection, wherein said optical detector comprises a three-dimensional scanner;
(b) a dispenser operatively associated with said optical detector and configured to deliver cells and/or compositions to said patient bodily surface based upon said data or said map;
(c) a three-dimensional plotter operatively connected with said three-dimensional scanner; and
(d) a controller operatively connected with said dispenser.

2. The delivery system of claim 1 , wherein said depth detector comprises an infrared detector.

3. The delivery system of claim 1 , wherein said three-dimensional scanner is a laser scanner.

4. The delivery system of claim 1 , wherein said three-dimensional scanner is a hand-held laser scanner.

5. The delivery system of claim 1 , wherein said dispenser comprises a plurality of nozzles.

6. The delivery system of claim 5 , further comprising one or more cartridges loaded with a composition, said composition optionally comprising cells,
wherein said nozzles are in fluid communication with said one or more cartridges.

7. The delivery system of claim 6 , wherein said nozzles are configured for pressure-based delivery of the compositions.

8. The delivery system of claim 6 , wherein said cells are amniotic fluid stem cells.

9. The delivery system of claim 6 , wherein said cells are skin cells.

10. The delivery system of claim 9 , wherein said cells are autologous.

11. The delivery system of claim 6 , wherein said cells are autologous.

12. The delivery system of claim 8 , wherein said cells are autologous.

13. The delivery system of claim 1 , further comprising:
means for interpreting the data of the patient bodily surface from said optical detector to form a model of the patient bodily surface;
means for transforming said model into a negative mold of the patient bodily surface, which mold is split into a plurality of Z-axis layers, which layers may optionally correspond to one or more tissue layers; and
means for overlaying each of said layers with a series of lines which represent coverage of the patient bodily surface, wherein said lines provide a path for the dispenser.

14. The delivery system of claim 13 , wherein the data of the patient bodily surface is wound surface data.

Assignees

• Univ Wake Forest Health Sciences

Inventors

• Yoo James J
• Atala Anthony
• Binder Kyle W
• Albanna Mohammad Z
• Zhao Weixin
• Dice Dennis
• Xu Tao

Classifications

• A61M35/20

  Non-portable devices, e.g. spraying booths · CPC title

• A61B5/6835

  Supports or holders, e.g., articulated arms · CPC title

• A61B2017/3225

  with processing of harvested tissue · CPC title

• A61B5/0064 Primary

  Body surface scanning · CPC title

• A61L27/24

  Collagen · CPC title