Isonitramine compound and composition containing same for preventing or treating metabolic diseases

Patent metadata

Field	Value
Publication number	US-10537559-B2
Application number	US-201816161094-A
Country	US
Kind code	B2
Filing date	Oct 16, 2018
Priority date	Aug 17, 2015
Publication date	Jan 21, 2020
Grant date	Jan 21, 2020

Abstract

Provided are a pharmaceutical composition for preventing or treating metabolic diseases and a health food for alleviating metabolic diseases, each of which the pharmaceutical composition and the health food includes, a stereoisomer of isonitramine or a derivative thereof, or a racemic mixture of the stereoisomers, wherein such a compound exhibits effects of inhibiting fat content or differentiation of an adipocyte, inhibiting activity of a carbohydrate metabolism enzyme, protecting pancreas, inhibiting blood sugar, and promoting insulin secretion, and thus can be favorably utilized in the treatment of metabolic diseases, such as obesity, diabetes, and hyperlipidemia.

First claim

What is claimed is:

1. A method of treating a metabolic disease in a subject in need thereof, comprising:
providing a pharmaceutical composition comprising, as an active ingredient, a stereoisomer represented by Formula 1 or a racemic mixture thereof:

wherein, in Formula 1,
X is a hydrogen atom;
Y is a hydrogen atom;
carbon atoms at the 6 th position and the 7 th position are each a chiral center; and
administering the pharmaceutical composition to the subject, wherein the metabolic disease is treated,
wherein the metabolic disease is selected from the group consisting of obesity, diabetes, hyperglycemia, insulin resistance, and hyperinsulinemia.

2. A method of treating a metabolic disease in a subject in need thereof, comprising:
providing a health food comprising, as an active ingredient, a stereoisomer represented by Formula 1 or a racemic mixture thereof:

wherein, in Formula 1,
X is a hydrogen atom;
Y is a hydrogen atom;
carbon atoms at the 6 th position and the 7 th position are each a chiral center; and
administering the health food to the subject, wherein the metabolic disease is treated,
wherein the metabolic disease is selected from the group consisting of obesity, diabetes, hyperglycemia, insulin resistance, and hyperinsulinemi.

Assignees

• Univ Inje Ind Acad Coop Found

Inventors

• Lee Hyo-Jong
• Park Yohan
• Park Hyeung-Geun

Classifications

• A61P3/04

  Anorexiants; Antiobesity agents · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61K31/438 Primary

  The ring being spiro-condensed with carbocyclic or heterocyclic ring systems · CPC title

• A23V2200/328

  having effect on glycaemic control and diabetes · CPC title