Visualization systems and methods for optimized optical coherence tomography

Patent metadata

Field	Value
Publication number	US-10533838-B2
Application number	US-201916519169-A
Country	US
Kind code	B2
Filing date	Jul 23, 2019
Priority date	Nov 30, 2016
Publication date	Jan 14, 2020
Grant date	Jan 14, 2020

Abstract

The present disclosure provides a visualization system for performing optimized optical coherence tomography (OCT) by determining the absolute distance between the OCT source and a sample. The present disclosure also provides a method for optimizing OCT, which includes determining an absolute distance between the OCT source and a sample using data relating to the focal length or position of an autofocus imager lens.

First claim

The invention claimed is:

1. A visualization system comprising:
an OCT system comprising
an OCT source operable to generate an OCT source beam;
an OCT beam splitter operable to split the OCT source beam into a sample beam that travels along a sample arm until it is reflected by a sample to form a reflected sample beam, and a reference beam that travels along a reference arm until it is reflected by a reference mirror in the OCT system to form a reflected reference beam, and operable to combine the reflected sample beam and the reflected reference beam to form a reflected OCT beam; and
an OCT detector operable to receive the reflected OCT beam and operable to detect an interference pattern of the reflected OCT beam;

a surgical microscope;
a dichroic mirror operable to allow non-OCT light to substantially pass through and operable to reflect the sample beam; and
a visualization beam splitter operable to direct non-OCT light into both the surgical microscope and;
an autofocus imager, the autofocus imager operable to:
receive non-OCT light reflected by the sample that has passed through the dichroic mirror and has been directed by the visualization beam splitter to the autofocus imager, and
use the non-OCT light reflected by the sample to optimize the focus of the autofocus imager on the sample by adjusting an autofocus imager lens, and
generate data relating to a position and a focal length of the autofocus imager lens; and

a processor operable to:
determine a change in distance between the dichroic mirror and the sample using the data relating to the position and the focal length of the autofocus imager lens;
determine a change in the length of the sample arm using the change in distance between the dichroic mirror and the sample;
generate a control signal operable to optimize the OCT system by adjusting the length of the reference arm or the focus of the sample arm; and
transmit the control signal to the OCT system.

2. The visualization system of claim 1 , wherein the autofocus imager lens is a power adjustable lens, and wherein a focal length of the power adjustable lens is adjusted.

3. The visualization system of claim 1 , wherein the autofocus imager lens is a position adjustable lens, and wherein a position of the position adjustable lens is adjusted.

4. The visualization system of claim 1 , wherein the processor is operable to determine the change in the length of the sample arm using the change in distance between the dichroic mirror and the sample, generate and transmit the control signal in real time.

5. A method for optimizing optical coherence tomography (OCT), comprising:
receiving, at an autofocus imager, non-OCT light reflected by a sample, the non-OCT light having passed through a dichroic mirror and having been directed by a visualization beam splitter to the autofocus imager;
using the non-OCT light reflected by the sample, at the autofocus imager, to optimize the focus of the autofocus imager on the sample by adjusting an autofocus imager lens;
generating data, by the autofocus imager, relating to a position and a focal length of the autofocus imager lens;
determining a distance between the dichroic mirror and the sample using the data relating to the position and the focal length of the autofocus imager lens;
determining an absolute distance between the OCT source and the sample using the distance between the dichroic mirror and the sample;
determining a length of the sample arm using the absolute distance between the OCT source and the sample;
generating a control signal, the control signal operable to optimize the OCT system by adjusting the length of the reference arm or the focus of the sample arm; and
transmitting the control signal to the OCT system.

6. The method of claim 5 , wherein the lens of the autofocus imager is a power adjustable lens, and the control device is operable to adjust the focal length of the lens.

7. The method of claim 5 , wherein the lens of the autofocus imager is a position adjustable lens, and the control device is operable to adjust the position of the lens.

8. The method of claim 5 , wherein calculating the length of the sample arm, using the absolute distance between the OCT source and the sample, and generating and transmitting the control signal is in real time.

9. The method of claim 5 , wherein determining the absolute distance between the OCT source and the sample is by reference to lens-distance reference data.

10. The visualization system of claim 9 , wherein the lens-distance reference data includes data corresponding to the distance between the OCT source and the sample at different focal lengths or positions of the autofocus imager lens.

Assignees

• Novartis Ag

Inventors

• Ren Hugang
• Yu Lingfeng

Classifications

• A61B3/102

  for optical coherence tomography [OCT] · CPC title

• A61B3/152

  for aligning · CPC title

• G01B9/02091 Primary

  Tomographic interferometers, e.g. based on optical coherence · CPC title

• A61B3/14

  Arrangements specially adapted for eye photography · CPC title

• G01J2009/0269

  Microscope type · CPC title