Remotely actuated valve for a biological liquid treatment system

Patent metadata

Field	Value
Publication number	US-10533680-B2
Application number	US-201415103230-A
Country	US
Kind code	B2
Filing date	Dec 19, 2014
Priority date	Dec 19, 2013
Publication date	Jan 14, 2020
Grant date	Jan 14, 2020

Abstract

The invention relates to valve system for controlling a process fluid within a liquid processing system. The valve system comprises a valve arrangement, a pneumatic control system, and a connector unit. When the valve arrangement is connected to the connector unit, two or more valves are formed, such that the pneumatic control system controls an open/close or pressure control mode of the valves. A pump diaphragm system is disclosed, as well as a system for purifying a biological material that comprises the valve system or the pump diaphragm system. Also discloses are methods of using the valve system or the pump diaphragm system in a process for the purification of a biological material.

First claim

We claim:

1. A valve system for controlling a process fluid within a liquid processing system, comprising
a) a valve arrangement comprising (i) a wetted part comprising two or more inlet conduits, an outlet conduit, and a plurality of valve components capable of controlling the flow in said conduits; and (ii) a plurality of first actuators that control the flow in said conduits;
b) a pneumatic control system comprising a plurality of second actuators, and a plurality of pneumatic conduits interconnecting said second actuators with said plurality of first actuators; and
c) a connector unit for connecting and disconnecting at least two of said pneumatic conduits interconnecting said second actuators with said plurality of first actuators;
wherein when the valve arrangement is connected to the connector unit, two or more valves are formed, such that the second actuator controls an open/close or pressure control mode of said valves.

2. The valve system of claim 1 , wherein the configuration or spatial arrangement of said valve arrangements or said connector unit may be altered to change the valve system's mode of operation.

3. The valve system of claim 1 , wherein the configuration of the connector unit is altered to change the valve system's mode of operation.

4. The valve system of claim 1 , wherein the configuration of the pneumatic control system is altered to change the valve system's mode of operation.

5. The valve system of claim 1 , wherein the valves are diaphragm valves.

6. The valve system of claim 1 , wherein the plurality of second actuators and pneumatic conduits of the pneumatic control system are situated inside a cabinet hosting the liquid processing system, while the connector unit is situated on an external panel of said cabinet.

7. The valve system of claim 1 , wherein the valve arrangement is a single use unit.

8. The valve system of claim 1 , wherein the valve arrangement is pre-sterilized.

9. The valve system of claim 1 , wherein the valve arrangement is provided as a closed and contained unit with aseptic connectors.

10. The valve system of claim 1 , wherein said valve arrangement is formed by two modules, the first module comprising said wetted part and the valve components, the second module comprising said plurality of first actuators.

11. The valve system of claim 10 , wherein said first and second modules are secured by a clamping device or a clamping plate.

12. The valve system of claim 10 , wherein the first module is formed from a flexible pouch that is secured by a clamping device or a clamping plate.

13. The valve system according to claim 1 , wherein at least one of the valves is formed as a pump chamber for achieving a pump function with a substantially unidirectional displacement of liquid in at least one conduit of said liquid processing system.

14. The valve system of claim 1 , wherein the valve or a displacement element of the pump is designed as a diaphragm, attached to a support structure of substantially higher rigidity.

15. The valve system of claim 14 , wherein the diaphragm is attached to the support structure by laser welding, 2D injection molding or by overmolding.

16. The valve system of claim 1 , wherein the valve arrangement and the connector unit each contain one or more positioning features to ensure that they are properly aligned when connected.

17. A system for purifying a biological material which system comprises the valve system of claim 1 .

Assignees

• Ge Healthcare Bio Sciences Ab

Inventors

• Gebauer Klaus Heinrich
• Sjolander Stefan

Classifications

• F16K7/12

  with flat, dished, or bowl-shaped diaphragm · CPC title

• F16K31/12 Primary

  actuated by fluid ({fluid-actuated lift valves F16K1/126} ; fluid-actuated check valves F16K15/00; fluid-actuated safety valves F16K17/00) · CPC title

• B01D29/90

  for feeding · CPC title

• B01D2201/16

  Valves · CPC title

• C12M29/00

  Means for introduction, extraction or recirculation of materials, e.g. pumps (pumps per se F04B) · CPC title