Compounds having antiparasitic or anti-infectious activity
US-9206131-B2 · Dec 8, 2015 · US
Quinolone-3-diarylethers
US10532983B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10532983-B2 |
| Application number | US-201615215103-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 20, 2016 |
| Priority date | Jul 20, 2015 |
| Publication date | Jan 14, 2020 |
| Grant date | Jan 14, 2020 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject.
First claim
Opening claim text (preview).
The invention claimed is: 1. A compound of the structure: wherein X is halogen and R is a carbonate ester, or a pharmaceutically acceptable salt thereof. 2. The compound of claim 1 wherein X is selected from fluoro and chloro, or a pharmaceutically acceptable salt thereof. 3. The compound of claim 1 wherein R is selected from methyl carbonate; ethyl carbonate; 2-methoxyethylcarbonate; 2-(2-methoxyethoxy)ethyl carbonate; (2-(2-(2-methoxyethoxy)ethoxy)ethyl) carbonate; allyl carbonate; tert-butyl carbonate; ((2,2-dimethyl-1,3-dioxolan-4-yl)methyl) carbonate; ((2-oxo-1,3-dioxolan-4-yl)methyl) carbonate; 2,3-dihydroxypropyl carbonate; and 1,1-dioxidotetrahydrothiophen-3-yl carbonate, or a pharmaceutically acceptable salt thereof. 4. The compound of claim 3 wherein X is chloro, or a pharmaceutically acceptable salt thereof. 5. A compound selected from the group consisting of: or a pharmaceutically acceptable salt thereof. 6. The compound of claim 3 wherein X is fluoro, or a pharmaceutically acceptable salt thereof. 7. The compound of claim 2 wherein X is fluoro, or a pharmaceutically acceptable salt thereof. 8. The compound of claim 2 wherein X is chloro, or a pharmaceutically acceptable salt thereof.
Assignees
Inventors
Classifications
Antiparasitic agents · CPC title
linked by a chain containing hetero atoms as chain links · CPC title
linked by a chain containing hetero atoms as chain links · CPC title
- C07D215/22Primary
attached in position 2 or 4 · CPC title
Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change · CPC title
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Frequently asked questions
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- What does patent US10532983B2 cover?
- Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject.
- Who is the assignee on this patent?
- Univ Oregon Health & Science, The Us Gov As Represented By The Department Of Veterans
- What technology area does this patent fall under?
- Primary CPC classification C07D215/22. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 14 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).