Topical compositions of Lithospermum erythrorhizon (gromwell root) for treating or controlling excessive oil production in skin and minimizing glycation in skin, and methods of using the compositions

Patent metadata

Field	Value
Publication number	US-10532024-B2
Application number	US-201715791913-A
Country	US
Kind code	B2
Filing date	Oct 24, 2017
Priority date	Oct 25, 2016
Publication date	Jan 14, 2020
Grant date	Jan 14, 2020

Abstract

Compositions for suppressing sebum production in skin (e.g., seborrheic skin), and minimizing glycation in skin (e.g., mature skin) with enhanced UV absorptive properties are described. In particular, the present invention relates to a composition containing a skin benefit agent that includes Lithospermum erythrorhizon. Also, methods of suppressing sebum production in skin (e.g., seborrheic skin) and minimizing glycation in skin (e.g., mature skin) by applying a composition to the skin, wherein the composition comprises an effective amount of a derivative of Lithospermum erythrorhizon are also described.

First claim

The invention claimed is:

1. A topical composition consisting of:
a. an active or an extract of the root of Lithospermum erythrorhizon in an amount ranging from about 0.05% to about 10.0% by weight of the total composition, and effective for treating or controlling an excessive oil production in skin and minimizing glycation in skin;
b. a lipophilic solubilizer;
c. a free radical stabilizer; and
d. optionally, a pharmaceutically acceptable carrier.

2. The composition of claim 1 , wherein the extract of the root of Lithospermum erythrorhizon comprises shikonin compound(s), and wherein the extract is standardized to 19-21% naphthoquinone.

3. The composition of claim 1 , wherein the composition is a water-in-silicone emulsion.

4. The composition of claim 1 , wherein the composition is an oil-in-water emulsion.

5. The composition of claim 1 , wherein the lipophilic solubilizer is a non-comedogenic ester or natural oil.

6. The composition of claim 5 , wherein the non-comedogenic ester is selected from the group consisting of adipates, caprylates, isononanoates, and select ethoxylated triglycerides.

7. The composition of claim 5 , wherein the non-comedogenic ester is diisobutyl adipate.

8. The composition of claim 1 , wherein the free radical stabilizer is a lipophilic antioxidant.

9. The composition of claim 8 , wherein the lipophilic antioxidant is selected from the group consisting of tocotrienols, carotenoids, and phenolics.

10. The composition of claim 8 , wherein the lipophilic antioxidant is tocopherol.

11. The composition of claim 1 , wherein the composition is for suppressing sebum production in a subject with dermatosis.

12. The composition of claim 1 , wherein the composition is for minimizing glycation in mature skin.

13. The composition of claim 1 , wherein the composition has a pH from about 4.0 to about 8.0.

14. The composition of claim 1 , wherein the composition is an oil-free composition.

15. The composition of claim 1 , wherein the composition is in a form of cream, lotion, pack or powder, emulsion, liniment foam, plaster, granules, or ointment.

16. The composition of claim 1 , wherein the composition is an over-the-counter cosmetic composition or a pharmaceutical composition.

17. The composition of claim 1 , wherein the composition is a water-in-silicone emulsion, and wherein the active or the extract of the root of Lithospermum erythrorhizon (2% CO 2 extraction product in 88% diisobutyl adipate and 10% tocopherol) is in an amount ranging from about 0.5% to about 2% by weight of the composition.

18. The composition of claim 1 , wherein the composition is a water-in-silicone emulsion, and wherein the active or the extract of the root of Lithospermum erythrorhizon (2% CO 2 extraction product in 88% diisobutyl adipate and 10% tocopherol) is in an amount ranging from about 2.5% to about 7.5% by weight of the composition.

19. The composition of claim 1 , wherein the composition is an oil-in-water emulsion, and wherein the active or the extract of the root of Lithospermum erythrorhizon (2% CO 2 extraction product in 88% diisobutyl adipate and 10% tocopherol) is in an amount ranging from about 0.05% to about 1% by weight of the composition.

20. The composition of claim 1 , wherein the composition is an oil-in-water emulsion, and wherein the active or the extract of the root of Lithospermum erythrorhizon (2% CO 2 extraction product in 88% diisobutyl adipate and 10% tocopherol) is in an amount ranging from 0.1% to about 5% by weight of the composition.

21. The composition of claim 1 , wherein the composition is an oil-in-water emulsion, and wherein the active or the extract of the root of Lithospermum erythrorhizon (2% CO 2 extraction product in 88% diisobutyl adipate and 10% tocopherol) is in an amount ranging from about 2.5% to about 7.5% by weight of the composition.

22. The composition of claim 1 , wherein the composition is an oil-in-water emulsion, and wherein the active or the extract of the root of Lithospermum erythrorhizon (2% CO 2 extraction product in 88% diisobutyl adipate and 10% tocopherol) is in an amount ranging from about 1.0% to about 5% by weight of the composition.

Assignees

• Access Business Group Int Llc

Inventors

• Velliquette Rodney A
• Glynn Kelly M
• Brumbaugh Ernest H
• Anderson Penelope M
• Rebhun John F
• Missler Stephen R
• Rajgopal Arun

Classifications

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61P17/08

  Antiseborrheics · CPC title

• A61P17/04

  Antipruritics · CPC title

• A61P17/00

  Drugs for dermatological disorders · CPC title

• A61K8/678

  Tocopherol, i.e. vitamin E · CPC title