Atrial appendage closure device and related methods

Patent metadata

Field	Value
Publication number	US-10531878-B2
Application number	US-201314417536-A
Country	US
Kind code	B2
Filing date	Jul 26, 2013
Priority date	Jul 26, 2012
Publication date	Jan 14, 2020
Grant date	Jan 14, 2020

Abstract

An atrial appendage closure device is provided that includes an insertion rod having a first end and a second end. An occluding member having an outer surface and an inner surface is connected to the first end of the insertion rod. The occluding member is moveable between a retracted position and a deployed position such that, in the deployed position, the occluding member is configured to provide a seal between a left atrial appendage and a left atrium of a heart. An anchoring member is further connected to the insertion rod and is configured to slide along the insertion rod to secure the device to a wall of a left atrial appendage. Methods for occluding a left atrial appendage that make use of the closure devices are also provided.

First claim

What is claimed is:

1. An atrial appendage closure device, comprising:
an insertion rod having a first end and a second end;
an occluding member connected to the first end of the insertion rod such that the insertion rod terminates at the occluding member, the occluding member including a plurality of ribs, the occluding member having an outer surface positioned away from the insertion rod and an inner surface positioned adjacent the insertion rod with the outer surface of the occluding member having a hooked portion at each end of the outer surface, and the occluding member being moveable between a retracted position and a deployed position,
wherein, in the deployed position, the occluding member is configured to provide a seal between a left atrial appendage and a left atrium of a heart; and
an anchoring member connected to an outside of the insertion rod and configured to slide along the outside of the insertion rod for securing the device to a wall of the left atrial appendage; and
the outer surface of the occluding member assumes a convex shape and the inner surface of the occluding member assumes a flattened shape.

2. The device of claim 1 , wherein the outer surface, the inner surface, or both the outer surface and the inner surface of the occluding member are coated with an extracellular matrix.

3. The device of claim 1 , wherein the outer surface, the inner surface, or both the outer surface and the inner surface of the occluding member are coated with a growth factor.

4. The device of claim 1 , wherein the occluding member comprises a flexible membrane supported by the plurality of ribs.

5. The device of claim 1 , wherein the anchoring member has a substantially flat proximal surface and a convex distal surface.

6. The device of claim 1 , wherein the anchoring member is movable between a retracted position and a deployed position.

7. The device of claim 1 , wherein the insertion rod defines a hollow interior cavity and an opening at the second end of the insertion rod, and wherein the insertion rod further defines a plurality of fenestrations in fluid communication with the hollow interior cavity and the opening at the second end of the insertion rod.

8. A method of occluding a left atrial appendage, comprising:
providing a closure device including,
an insertion rod having a first end and a second end, and
an occluding member connected to the first end of the insertion rod such that the insertion rod terminates at the occluding member, the occluding member including a plurality of ribs, the occluding member having an outer surface positioned away from the insertion rod and an inner surface positioned adjacent the insertion rod with the outer surface of the occluding member having a hooked portion at each end of the outer surface, and the occluding member being moveable between a retracted position and a deployed position, and an anchoring member connected to an outside of the insertion rod and configured to slide along the outside of the insertion rod for securing the device to a wall of the left atrial appendage;
inserting the occluding member and a portion of the insertion rod into the left atrial appendage and into a left atrium of a heart while the occluding member is in a retracted position;
deploying the occluding member inside the left atrium such that the occluding member is configured to provide a seal between the left atrial appendage and the left atrium of the heart;
securing the inner surface of the occluding member against a wall of the left atrial appendage to thereby provide a seal between the left atrial appendage and the left atrium of the heart; and
securing the anchoring member to the wall of the left atrial appendage; and
the outer surface of the occluding member assumes a convex shape and the inner surface of the occluding member assumes a flattened shape.

9. The method of claim 8 , wherein the step of securing the inner surface of the occluding member against the wall of the left atrial appendage comprises pulling the occluding member toward a tip of the left atrial appendage subsequent to deploying the including member inside the left atrium.

10. The method of claim 8 , wherein the step of securing the inner surface of the occluding member against the wall of the left atrial appendage comprises collapsing the wall of the left atrial appendage against the inner surface of the occluding member.

11. The method of claim 8 , wherein the step of inserting the occluding member and the portion of the insertion rod into the left atrial appendage and the left atrium comprises:
piercing the wall of the left atrial appendage; and
inserting the occluding member and the portion of the insertion rod through the wall of the left atrial appendage.

12. The method of claim 11 , wherein the step of piercing the wall of the left atrial appendage comprises piercing the wall of the left atrial appendage with a hollow needle.

13. The method of claim 12 , wherein the step of inserting the occluding member and the portion of the insertion rod through the wall of the left atrial appendage comprises inserting the occluding member and the portion of the insertion rod through the hollow needle and into the left atrial appendage and the left atrium.

14. The method of claim 8 , wherein securing the anchoring member to the wall of the left atrial appendage includes moving the anchoring member between a retracted position and a deployed position.

15. The method of claim 8 , wherein securing the anchoring member to the wall of the left atrial appendage includes:
inserting the anchoring member through the hollow needle;
deploying the anchoring member adjacent to the wall of left atrial appendage; and
securing the anchoring member to the wall of the left atrial appendage opposite the occluding member.

Assignees

• Univ Louisville Res Found Inc
• Univ Of Louisville Research Foundation

Inventors

• Slaughter Mark S
• Giridharan Guruprasad A
• Koenig Steven C
• Sobieski Michael A
• Soucy Kevin

Classifications

• A61B17/122

  Clamps or clips, e.g. for the umbilical cord {(for the vas deferens A61F6/206)} · CPC title

• A61B2217/005

  with suction drainage system · CPC title

• A61B17/12122 Primary

  within the heart (for closing a cardiac septal defect A61B17/0057) · CPC title

• A61B17/12172

  having a pre-set deployed three-dimensional shape (methods of manufacturing A61B2017/00526) · CPC title

• A61B2017/00247

  Making holes in the wall of the heart, e.g. laser Myocardial revascularization · CPC title