Targeted nitroxide agents
US-9890192-B2 · Feb 13, 2018 · US
Targeted nitroxide agents
US10526368B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10526368-B2 |
| Application number | US-201715855598-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 27, 2017 |
| Priority date | Jul 17, 2008 |
| Publication date | Jan 7, 2020 |
| Grant date | Jan 7, 2020 |
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- Title
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- Abstract
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Abstract
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Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.
First claim
Opening claim text (preview).
We claim: 1. A compound having the structure: wherein X is R 1 is isobutyl; R 2 is hydrogen R 4 is hydrogen, R 3 is —NH—R 5 , and R 5 is and; R is —P(O)(Ph) 2 .
Assignees
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Classifications
Free radical scavengers or antioxidants · CPC title
Antioxidants, e.g. antiradicals (preparations for protection against sunlight A61Q17/00) · CPC title
Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent (peptidic linkers A61K47/65) · CPC title
attached in position 4 · CPC title
Bridged systems · CPC title
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- What does patent US10526368B2 cover?
- Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by rad…
- Who is the assignee on this patent?
- Univ Of Pittsburgh—Of The Commonwealth System Of Higher Education
- What technology area does this patent fall under?
- Primary CPC classification C07K5/08. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 07 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).