Method for producing fullerene derivative

Patent metadata

Field	Value
Publication number	US-10526293-B2
Application number	US-201515509080-A
Country	US
Kind code	B2
Filing date	Sep 4, 2015
Priority date	Sep 8, 2014
Publication date	Jan 7, 2020
Grant date	Jan 7, 2020

Abstract

(in formula (1), C* are each carbon atoms adjacent to each other for forming a fullerene skeleton, A is a linking group having 1-4 carbon atoms for forming a ring structure with two C*, in which a portion thereof may be a substituted or condensed group).

First claim

What is claimed is:

1. A method for producing a fullerene derivative having a partial structure represented by Formula (1), by reacting two carbon atoms adjacent to each other for forming a fullerene skeleton with a halogenated compound represented by Formula (2) in a mixed solvent of an aromatic solvent and an aprotic polar solvent having a C═O or S═O bond in the presence of at least one metal selected from the group consisting of manganese, iron and zinc:

(in Formula (1), C* each represent carbon atoms adjacent to each other for forming a fullerene skeleton, A represents a linking group with 1 to 4 carbon atoms for forming a ring structure or a functional group in which the linking group is partially substituted or condensed)

(in Formula (2), A represents a linking group with 1 to 4 carbon atoms or a functional group in which the linking group is partially substituted or condensed, and each X independently represents a halogen atom).

2. The method for producing a fullerene derivative according to claim 1 , wherein the linking group with 1 to 4 carbon atoms for A in Formulas (1) and (2) is partially substituted by an aromatic group, a heteroaromatic group, an alkoxycarbonyl group or an alkylidene group.

3. The method for producing a fullerene derivative according to claim 1 , wherein the linking group with 1 to 4 carbon atoms for A in Formulas (1) and (2) partially forms a condensed-ring structure or a polycyclic structure comprising an aromatic ring or a heteroaromatic ring with an aromatic ring or a heteroaromatic ring.

4. The method for producing a fullerene derivative according to claim 1 , wherein the aprotic polar solvent is one or more of the group consisting of dimethyl sulfoxide (DMSO) and dimethylformamide (DMF).

5. The method for producing a fullerene derivative according to claim 1 , wherein the aromatic solvent is o-dichlorobenzene.

6. The method for producing a fullerene derivative according to claim 1 , wherein the halogen atom (X) is Br.

7. The method for producing a fullerene derivative according to claim 1 , wherein the metal is Mn, and the aprotic polar solvent is DMF.

8. The method for producing a fullerene derivative according to claim 1 , wherein the metal is Fe, and the aprotic polar solvent is DMSO.

9. The method for producing a fullerene derivative according to claim 1 , wherein the metal is Mn or Zn, and the aprotic polar solvent is DMSO.

Assignees

• Showa Denko Kk
• Mitsubishi Corp

Inventors

• Jin Tienan
• Si Weili
• Yamamoto Yoshinori
• Igarashi Takeshi

Classifications

• C07C13/64

  with a bridged ring system · CPC title

• C07C17/266

  of hydrocarbons and halogenated hydrocarbons · CPC title

• A61K31/55

  having seven-membered rings, e.g. azelastine, pentylenetetrazole · CPC title

• C07C1/26

  starting from organic compounds containing only halogen atoms as hetero-atoms · CPC title

• A61K31/5377

  not condensed and containing further heterocyclic rings, e.g. timolol · CPC title