Piercing device

Patent metadata

Field	Value
Publication number	US-10525435-B2
Application number	US-201615546924-A
Country	US
Kind code	B2
Filing date	Mar 10, 2016
Priority date	Mar 13, 2015
Publication date	Jan 7, 2020
Grant date	Jan 7, 2020

Abstract

The present invention provides a system for the production of a radiopharmaceutical including a radiosynthesis apparatus and a disposable cassette. The system of the invention includes a device that enables a position on the cassette to be freed for inclusion of an additional reagent vial. With the system of the invention a broader range of radiochemical syntheses can be envisaged using the cassette.

First claim

The invention claimed is:

1. A system for the production of a radiopharmaceutical comprising:
(i) a cassette comprising all the reagents required to produce two batches of said radiopharmaceutical when a radioisotope is introduced into said cassette, wherein each of said reagents is contained in a stoppered reagent vial that is pierced by a spike by automated movement of said stoppered reagent vial and/or said spike;
(ii) an automated radiosynthesiser onto which said cassette removably fits and which comprises moving parts that control operation of the cassette, wherein one such moving part is a device to facilitate the automated piercing of one of said stoppered reagent vials wherein said device is attached to the outside of said automated radiosynthesiser and comprises a support and a substantially rigid rod housed within said support, wherein said support comprises a support body and a rod fixing means.

2. The system as defined in claim 1 , wherein said rod fixing means comprises a bore in said support body wherein said bore has cross-sectional dimensions substantially similar to the cross-sectional dimensions of said rod but allowing said rod to be securely contained within said bore.

3. The system as defined in claim 1 , wherein said support is held in place on the outside of said automated radiosynthesiser by cooperative engagement of a support fixing element and an automated radiosynthesiser fixing element.

4. The system as defined in claim 1 , wherein said rod is made from rigid plastic.

5. The system as defined in claim 1 , wherein said device further comprises a water bottle holder housed within said support.

6. The system as defined in claim 5 , wherein said water bottle holder is located diametrically opposite said rod.

7. The system as defined in claim 5 , wherein said water bottle holder comprises a rigid spacer having a first end housed within said support and a second end comprising a water bottle hanger.

8. The system as defined in claim 1 , wherein said radiopharmaceutical is an 18 F-labelled radiopharmaceutical.

9. The system as defined in claim 8 , wherein said 18 F-labelled radiopharmaceutical is 18 F-fluorodeoxyglucose ( 18 F-FDG).

10. The system as defined in claim 9 , wherein said reagents comprise an 18 F elution solution, mannose triflate, acetonitrile, ethanol and buffer.

11. A device as defined in the system claim 1 .

Assignees

• Ge Healthcare Ltd

Inventors

• Franci Xavier
• Dumont Philippe
• Lignon Steve
• Lange Audrey Marie
• Verbrugge Nicolas

Classifications

• B01J2219/00952

  Sensing operations · CPC title

• B01J2219/00927

  Particle radiation or gamma-radiation · CPC title

• B01J2219/00918

  by adsorption · CPC title

• B01J2219/00916

  by chromatography · CPC title

• B01J2219/00894

  More than two inlets · CPC title