Use of parvovirus for eliminating cancer stem cells (CSCs)
US-9700588-B2 · Jul 11, 2017 · US
Use of parvovirus for eliminating cancer stem cells (CSCs)
US10525091B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10525091-B2 |
| Application number | US-201715617265-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 8, 2017 |
| Priority date | Jul 7, 2010 |
| Publication date | Jan 7, 2020 |
| Grant date | Jan 7, 2020 |
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Abstract
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Described is the use of a parvovirus, preferably H-1PV, for the therapeutical elimination of cancer stem cells (CSCs), preferably neuroblastoma stem cells and glioblastoma stem cells.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method of combating cancer stem cells (CSCs) in a subject having metastatic cancer disease, comprising administering to said subject a composition comprising parvovirus H-1 (H-1PV) effective for therapeutically destroying said CSCs which are characterized by the expression of stem cell markers CD133, nestin, and/or SOX2. 2. The method of claim 1 , wherein said CSCs are selected from the group consisting of CSCs resistant to chemotherapy or radiotherapy, potentially relapsing CSCs and neuroblastoma stem cells. 3. The method of claim 1 , wherein said composition is administered by intravenous (i.v.) or intratumoral administration. 4. The method of claim 1 , wherein said composition further comprises a pharmaceutically acceptable carrier. 5. A method of combating cancer stem cells (CSCs) in a subject suffering cancer relapse, comprising administering to said subject a composition comprising parvovirus H-1 (H-1PV) effective for therapeutically destroying said CSCs which are characterized by the expression of stem cell markers CD133, nestin, and/or SOX2. 6. The method of claim 5 , wherein said CSCs are selected from the group consisting of CSCs resistant to chemotherapy or radiotherapy, potentially relapsing CSCs or neuroblastoma stem cells. 7. The method of claim 5 , wherein said composition is administered by intravenous (i.v.) or intratumoral administration. 8. The method of claim 5 , wherein said composition further comprises a pharmaceutically acceptable carrier.
Assignees
Inventors
Classifications
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Antineoplastic agents · CPC title
Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent · CPC title
- A61K35/768Primary
Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766 · CPC title
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Frequently asked questions
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- What does patent US10525091B2 cover?
- Described is the use of a parvovirus, preferably H-1PV, for the therapeutical elimination of cancer stem cells (CSCs), preferably neuroblastoma stem cells and glioblastoma stem cells.
- Who is the assignee on this patent?
- Deutsches Krebsforsch, Univ Heidelberg Ruprecht Karls
- What technology area does this patent fall under?
- Primary CPC classification A61K35/768. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jan 07 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).