Spirocyclic compounds

Patent metadata

Field	Value
Publication number	US-10525036-B2
Application number	US-201615563926-A
Country	US
Kind code	B2
Filing date	Mar 31, 2016
Priority date	Apr 3, 2015
Publication date	Jan 7, 2020
Grant date	Jan 7, 2020

Abstract

Disclosed herein are spirocyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

First claim

What is claimed is:

1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof:

wherein:
R 1 is selected from the group consisting of hydrogen, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl, an optionally substituted cycloalkyl(alkyl), an optionally substituted cycloalkenyl(alkyl), an optionally substituted aryl(alkyl), an optionally substituted heteroaryl(alkyl), an optionally substituted heterocyclyl(alkyl), hydroxy, an optionally substituted alkoxy, cyano, an optionally substituted C-carboxy, an optionally substituted N-amido, an optionally substituted urea, nitro, an optionally substituted sulfenyl, an optionally substituted haloalkyl, amino, an optionally substituted mono-substituted amino group, an optionally substituted di-substituted amino group and —(CR 1a1 R 1a2 )q-R 1b , wherein q is 1, 2, 3, 4, 5 or 6, each R 1a1 and each R 1a2 are independently hydrogen, halogen or an unsubstituted alkyl, and R 1b is selected from the group consisting of hydroxy, an optionally substituted N-amido, an optionally substituted N-sulfinamido, an optionally substituted N-sulfonamido, an optionally substituted urea, an optionally substituted sulfenyl, amino, an optionally substituted mono-substituted amino group and an optionally substituted di-substituted amino group;
Y 1 , Y 2 and Y 3 are independently C or N,
provided that when Y 1 is C, then R 2a is selected from the group consisting of hydrogen, halogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl, an optionally substituted cycloalkyl(alkyl), an optionally substituted aryl(alkyl), an optionally substituted heteroaryl(alkyl), an optionally substituted heterocyclyl(alkyl), hydroxy, an optionally substituted alkoxy, cyano, nitro, an optionally substituted sulfenyl, amino, an optionally substituted mono-substituted amino group and an optionally substituted di-substituted amino group, and when Y 1 is N, then R 2a is absent,
provided that when Y 2 is C, then R 2b is selected from the group consisting of hydrogen, halogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl, an optionally substituted cycloalkyl(alkyl), an optionally substituted aryl(alkyl), an optionally substituted heteroaryl(alkyl), an optionally substituted heterocyclyl(alkyl), hydroxy, an optionally substituted alkoxy, cyano, nitro, an optionally substituted sulfenyl, amino, an optionally substituted mono-substituted amino group and an optionally substituted di-substituted amino group, and when Y 2 is N, then R 2b is absent,
provided that when Y 3 is C, then R 2c is selected from the group consisting of hydrogen, halogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl, an optionally substituted cycloalkyl(alkyl), an optionally substituted aryl(alkyl), an optionally substituted heteroaryl(alkyl), an optionally substituted heterocyclyl(alkyl), hydroxy, an optionally substituted alkoxy, cyano, nitro, an optionally substituted sulfenyl, amino, an optionally substituted mono-substituted amino group and an optionally substituted di-substituted amino group, and when Y 3 is N, then R 2c is absent,

each R 3a , each R 3b , R 3c , R 3d , each R 3e , each R 3f , R 3g , R 3h , R 3i and R 3j are independently selected from the group consisting of hydrogen, halogen, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl, an optionally substituted cycloalkyl(alkyl), an optionally substituted aryl(alkyl), an optionally substituted heteroaryl(alkyl), an optionally substituted heterocyclyl(alkyl) hydroxy, an optionally substituted alkoxy, an optionally substituted haloalkoxy, cyano, an optionally substituted N-amido, an optionally substituted C-carboxy, an optionally substituted oxime, an optionally substituted acyl hydrozone, an optionally substituted sulfenyl, an optionally substituted sulfinyl, an optionally substituted sulfonyl, amino, an optionally substituted mono-substituted amino group, an optionally substituted di-substituted amino group and —(CH 2 )r-R 3k , wherein r is 1, 2, 3, 4, 5 or 6, and R 3k is selected from the group consisting of halo, hydroxy, cyano, an optionally substituted heteroaryl, an optionally substituted alkoxy, an optionally substituted sulfenyl and an optionally substituted hydrazine;
each R 4a and each R 4b are independently hydrogen, deuterium or an optionally substituted alkyl;
R 5a , R 5b , R 5c , R 5e , R 5f , R 5g and R 5h are independently selected from the group consisting of hydrogen, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted cycloalkyl(alkyl), an optionally substituted aryl(alkyl), an optionally substituted heteroaryl(alkyl), an optionally substituted heterocyclyl(alkyl) and an optionally substituted C-carboxy; or
R 5b and R 5c are taken together to form an optionally substituted cycloalkyl, an optionally substituted aryl or an optionally substituted heterocyclyl, and R 5a , R 5e , R 5f , R 5g and R 5h are independently selected from the group consisting of hydrogen, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted cycloalkyl(alkyl), an optionally substituted aryl(alkyl), an optionally substituted heteroaryl(alkyl), an optionally substituted heterocyclyl(alkyl) and an optionally substituted C-carboxy; or
R 5f and R 5g are taken together to form an optionally substituted cycloalkyl, an optionally substituted aryl or an optionally substituted heterocyclyl, R 5a , R 5b , R 5c , R 5e and R 5h are independently selected from the group consisting of hydrogen, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted cycloalkyl(alkyl), an optionally substituted aryl(alkyl), an optionally substituted heteroaryl(alkyl), an optionally substituted heterocyclyl(alkyl) and an optionally substituted C-carboxy; or
R 5b and R 5c are taken together to form an optionally substituted cycloalkyl, an optionally substituted aryl or an optionally substituted heterocyclyl, and R 5f and R 5g are taken together to form an optionally substituted cycloalkyl, an optionally substituted aryl or an optionally substituted heterocyclyl, and R 5a , R 5e and R 5h are independently selected from the group consisting of hydrogen, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted cycloalkyl(alkyl), an optionally substituted aryl(alkyl), an optionally substituted heteroaryl(alkyl)

Assignees

• Recurium Ip Holdings Llc

Inventors

• Huang Peter Qinhua
• Kahraman Mehmet
• Slee Deborah Helen
• Bunker Kevin Duane
• Hopkins Chad Daniel
• Pinchman Joseph Robert
• Abraham Sunny
• Sit Rakesh Kumar
• Severance Daniel Lee

Classifications

• C07D471/10

  Spiro-condensed systems · CPC title

• C07D487/10 Primary

  Spiro-condensed systems · CPC title

• A61K31/4162 Primary

  condensed with heterocyclic ring systems · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61K31/416

  condensed with carbocyclic ring systems, e.g. indazole · CPC title