System and method for hyperpolarizing a substance and quenching radicals therein

Patent metadata

Field	Value
Publication number	US-10520561-B2
Application number	US-201715716607-A
Country	US
Kind code	B2
Filing date	Sep 27, 2017
Priority date	Sep 27, 2017
Publication date	Dec 31, 2019
Grant date	Dec 31, 2019

Abstract

A system for hyperpolarizing a substance is provided. The system includes a cryostat, a polarizer, and a shuttle. The cryostat is operative to generate radicals within the substance by exposing the substance to electromagnetic radiation. The polarizer is operative to hyperpolarize the substance via the radicals, and to quench the radicals within the substance by adjusting a temperature of the substance after the substance has been hyperpolarized. The shuttle is operative to transport the substance while maintaining hyperpolarization of the substance.

First claim

What is claimed is:

1. A system for hyperpolarizing a substance comprising:
a cryostat operative to generate radicals within the substance by exposing the substance to electromagnetic radiation;
a polarizer operative to hyperpolarize the substance via the radicals, and to quench the radicals within the substance by adjusting a temperature of the substance after the substance has been hyperpolarized;
a shuttle operative to transport the substance while maintaining hyperpolarization of the substance; and
an exchange switch operative to facilitate movement of the substance between the cryostat, the polarizer, and the shuttle.

2. The system of claim 1 , wherein the exchange switch comprises:
one or more conduits;
a transport medium port operative to fluidly connect the one or more conduits to a transport medium source;
a vacuum port operative to fluidly connect the one or more conduits to a vacuum source;
one or more substance ports operative to fluidly connect the one or more conduits to at least one of the cryostat, the polarizer, and the shuttle;
one or more valves disposed within the one or more conduits; and
wherein the one or more valves are operative to fluidly connect at least one of the cryostat, the polarizer, and the shuttle to at least one of the transport medium source and the vacuum source.

3. The system of claim 1 , wherein the cryostat is integrated with the shuttle.

4. The system of claim 1 , wherein the electromagnetic radiation is ultraviolet light.

5. The system of claim 1 further comprising:
a packet generator operative to generate packets of the substance.

6. The system of claim 5 , wherein the packets have a shape configured to promote complete exposure of the substance to the electromagnetic radiation.

7. The system of claim 6 , wherein the shape substantially conforms to at least one of a bead, a sheet, a cylinder, a quadrangle, and a triangle.

8. The system of claim 1 further comprising:
a dispenser that fluidly connects to the shuttle and is operative to dispense the substance.

9. A method of hyperpolarizing a substance comprising:
generating radicals within the substance by exposing the substance to electromagnetic radiation while disposed in a cryostat;
moving the substance between the cryostat and a shuttle via an exchange switch;
moving the substance between the shuttle and a polarizer via the exchange switch;
hyperpolarizing the substance via the radicals using the polarizer;
quenching the radicals within the substance by adjusting the temperature of the substance after the substance has been hyperpolarized; and
storing the substance within the shuttle,
wherein the shuttle is operative to facilitate transport of the substance while maintaining hyperpolarization of the substance.

10. The method of claim 9 further comprising:
transporting the substance via the shuttle.

11. The method of claim 9 , wherein hyperpolarizing the substance via the radicals using a polarizer comprises:
exposing the substance to microwaves.

12. The method of claim 9 , wherein the exchange switch facilitates movement of the substance via at least one of a transfer medium and a vacuum.

13. The method of claim 9 further comprising:
generating packets of the substance via a packet generator.

14. The method of claim 13 , wherein generating packets of the substance via a packet generator comprises:
forming the packets so as to have a shape configured to promote complete exposure of the substance to the electromagnetic radiation.

15. The method of claim 14 , wherein the shape substantially conforms to at least one of a bead, a sheet, a cylinder, a quadrangle, and a triangle.

16. The method of claim 9 further comprising:
dispensing the substance from the shuttle via a dispenser fluidly connected to the shuttle.

17. A shuttle for transporting a hyperpolarized substance comprising:
a body having a magnet disposed therein;
a chamber disposed within the body and operative to store the substance; and
an integrated cryostat that is operative to generate radicals in the substance via exposing the substance to electromagnetic radiation;
wherein the magnet is operative to generate a magnetic field that maintains the substance in a hyperpolarized state.

18. A system for hyperpolarizing a substance comprising:
a packet generator operative to generate packets of the substance;
a cryostat operative to generate radicals within the substance by exposing the substance to electromagnetic radiation;
a polarizer operative to hyperpolarize the substance via the radicals, and to quench the radicals within the substance by adjusting a temperature of the substance after the substance has been hyperpolarized;
a shuttle operative to transport the substance while maintaining hyperpolarization of the substance.

19. A method of hyperpolarizing a substance comprising:
generating packets of the substance via a packet generator;
generating radicals within the substance by exposing the substance to electromagnetic radiation while disposed in a cryostat;
hyperpolarizing the substance via the radicals using a polarizer;
quenching the radicals within the substance by adjusting the temperature of the substance after the substance has been hyperpolarized; and
storing the substance within a shuttle operative to facilitate transport of the substance while maintaining hyperpolarization of the substance.

Assignees

• Gen Electric
• Memorial Sloan Kettering Cancer Center

Inventors

• Comment Arnaud
• Chen Albert P
• Keshari Kayvan Rahimi

Classifications

• G01R33/282 Primary

  Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent · CPC title

• G01R33/446

  Multifrequency selective RF pulses, e.g. multinuclear acquisition mode (spatially selective RF pulses G01R33/4833) · CPC title

• G01R33/445

  MR involving a non-standard magnetic field B0, e.g. of low magnitude as in the earth's magnetic field or in nanoTesla spectroscopy, comprising a polarizing magnetic field for pre-polarisation, B0 with a temporal variation of its magnitude or direction such as field cycling of B0 or rotation of the direction of B0, or spatially inhomogeneous B0 like in fringe-field MR or in stray-field imaging · CPC title