Shear horizontal surface acoustic wave (sh-saw) resonators and arrays thereof
US-2017052174-A1 · Feb 23, 2017 · US
System and method of measuring cell viability and growth
US10520472B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10520472-B2 |
| Application number | US-201715682070-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 21, 2017 |
| Priority date | Feb 19, 2015 |
| Publication date | Dec 31, 2019 |
| Grant date | Dec 31, 2019 |
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Abstract
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A novel SH-SAW biosensor capable of non-invasive and touch-free detection of cancer cell viability and growth or proliferation in two-dimensional (2D) and three-dimensional (3D) cell cultures as well as stem cell regeneration as it pertains to cancer cell biology and anti-cancer drug development is presented. The biosensor includes two pairs of resonators including interdigital transducers reflecting fingers to quantify mass loading by the cells in suspension as well as within a tumoroid culture platform. The biosensor can be part of a perfused 3PNS-tumoroid system that is amenable to real-time non-invasive monitoring of the cell proliferation, viability, and multiplexed detection of key physiologic and clinical biomarkers.
First claim
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What is claimed is: 1. A non-invasive and touch-free method of detecting and quantifying cell growth and viability comprising: providing a microfluidic chip containing a shear horizontal-surface acoustic wave device comprising: two pairs of resonators formed on a lithium tantalate substrate wherein each resonator is comprised of at least two interdigital transducers, each having at least one pair of reflecting fingers; at least one pH measurement electrode, at least one oxygen…
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Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
- G01N29/022Primary
Physics · mapped topic
Physics · mapped topic
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- What does patent US10520472B2 cover?
- A novel SH-SAW biosensor capable of non-invasive and touch-free detection of cancer cell viability and growth or proliferation in two-dimensional (2D) and three-dimensional (3D) cell cultures as well as stem cell regeneration as it pertains to cancer cell biology and anti-cancer drug development is presented. The biosensor includes two pairs of resonators including interdigital transducers refl…
- Who is the assignee on this patent?
- Mohapatra Shyam S, Mohapatra Subhra, Guldiken Rasim Oytun, and 4 more
- What technology area does this patent fall under?
- Primary CPC classification G01N29/022. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Dec 31 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).