Sample liquid-surface position measurement device and sample liquid-surface position measurement method

Patent metadata

Field	Value
Publication number	US-10514386-B2
Application number	US-201716099984-A
Country	US
Kind code	B2
Filing date	Apr 11, 2017
Priority date	May 26, 2016
Publication date	Dec 24, 2019
Grant date	Dec 24, 2019

Abstract

A sample liquid-surface position measurement device includes: a first light source that illuminates a side face of a container containing a sample; a first optical measurement sensor that is located on the opposite side of the container from the first light source, and measures transmitted light from the first light source; a first label position measuring unit that measures a position of a label affixed to the container; and an analysis section that calculates a liquid-surface position or an interface position of the sample in the container, from transmitted-light intensity data in a longitudinal direction of the container which is measured by the first optical measurement sensor, and from the position of the label in the longitudinal direction of the container which is measured by the first label position measuring unit.

First claim

The invention claimed is:

1. A sample liquid-surface position measurement device, comprising:
a first light source that illuminates a side face of a container containing a sample;
a first optical measurement sensor that is located on the opposite side of the container from the first light source, and measures transmitted light from the first light source;
a first label position measuring unit that measures a position of a label affixed to the container; and
an analysis section that calculates a liquid-surface position or an interface position of the sample in the container, from transmitted-light intensity data in a longitudinal direction of the container which is measured by the first optical measurement sensor, and from the position of the label in the longitudinal direction of the container which is measured by the first label position measuring unit,
wherein the first label position measuring unit includes
a second light source that illuminates a side face of the container, and
a second optical measurement sensor that measures scattered light or reflected light resulting from impinging of light from the second light source on the container, and
the second light source emits light to an intersection between an optical axis of the light from the first light source and the surface of the container.

2. The sample liquid-surface position measurement device according to claim 1 ,
wherein the second light source illuminates the container at an inclination of from 5 degrees to 40 degrees with respect to an optical axis of the light from the first light source.

3. The sample liquid-surface position measurement device according to claim 1 , further comprising a second label position measuring unit that measures a position of a label affixed to the container,
wherein the first label position measuring unit is placed on the side of the first light source and measures a position of the label in a position where the light from the first light source enters the container, and
the second label position measuring unit is placed on the side of the first optical measurement sensor and measures a position of the label in a position where the light from the first light source passes through and emerges from the container.

4. The sample liquid-surface position measurement device according to claim 1 ,
wherein the analysis section reduces a threshold within a range where the label is affixed, and makes a comparison between the threshold and the transmitted-light intensity data in order to calculate a liquid-surface position or an interface position of the sample.

5. The sample liquid-surface position measurement device according to claim 1 ,
wherein the sample includes serum obtained after centrifugation of blood, and
the liquid-surface position or the interface position includes at least one of an interface between blood clot and a separating agent, an interface between the serum and the separating agent, and a top liquid surface of the serum.

6. The sample liquid-surface position measurement device according to claim 5 ,
wherein the analysis section calculates the amount of liquid of the serum from the liquid-surface position or the interface position.

7. The sample liquid-surface position measurement device according to claim 5 ,
wherein the light of the first light source has a wavelength selected from the range of from 1400 nm to 1600 nm.

8. The sample liquid-surface position measurement device according to claim 1 ,
wherein the analysis section includes a filter section that filters the transmitted-light intensity data to obtain a filtered waveform of the transmitted-light intensity data, and
the analysis section uses a position of a feature point of the filtered waveform to make correction for the liquid-surface position or the interface position of the sample.

9. The sample liquid-surface position measurement device according to claim 8 ,
wherein the analysis section converts the transmitted-light intensity data to logarithmic scale, and then inputs the converted transmitted-light intensity data to the filter section in order to acquire the filtered waveform.

10. The sample liquid-surface position measurement device according to claim 1 , further comprising a movement mechanism,
wherein while the movement mechanism is used to change a relative position in the vertical direction between the container, the first light source, the first optical measurement sensor, and the first label position measuring unit, the first optical measurement sensor measures transmitted light passing from the first light source, and the first label position measuring unit measures a position of the label.

11. The sample liquid-surface position measurement device according to claim 1 ,
wherein the first label position measuring unit includes a second optical measurement sensor that measures scattered light or reflected light resulting from impinging of light from the first light source on the container to measure a position of a label affixed to the container, and
the second light source is shared with the first light source.

12. A biological sample analysis device comprising:
a preprocessing unit including the sample liquid-surface position measurement device according to claim 1 , and
an automatic analyzer that analyzes components of the sample.

13. A sample liquid-surface position measurement method, comprising:
causing a first light source to illuminate a side face of a container containing a sample;
causing a first optical measurement sensor, which is placed on the opposite side of the first light source with the container therebetween, to measure transmitted light from the first light source;
causing a first label position measuring unit to measure a position of a label affixed to the container; and
causing an analysis section to calculate a liquid-surface position or an interface position of the sample in the container, based on transmitted-light intensity data in a longitudinal direction of the container which is measured by the first optical measurement sensor, and the position of the label in the longitudinal direction of the container which is measured by the first label position measuring unit,
wherein the first label position measuring unit includes:
a second light source that illuminates a side face of the container; and
a second optical measurement sensor that measures either light scattered or light reflected by impinging of light from the second light source on the container, and
the second light source emits light to an intersection between an optical axis of the light from the first light source and the surface of the container.

Assignees

• Hitachi High Tech Corp

Inventors

• Nakagawa Tatsuo
• Sugiyama Kiyotaka
• SUENARI Tsukasa
• Suzuki Iwao

Classifications

• G01N35/10

  Devices for transferring samples {or any liquids} to, in, or from, the analysis apparatus, e.g. suction devices, injection devices {(G01N35/0099 takes precedence)} · CPC title

• G01B11/00

  Measuring arrangements characterised by the use of optical techniques · CPC title

• G01N2035/1025

  Fluid level sensing · CPC title

• G01N15/042

  by centrifuging and investigating centrifugates (centrifuges per se B04B) · CPC title

• G01N35/1016

  Control of the volume dispensed or introduced · CPC title