Cellulose ether acetate phthalates

Patent metadata

Field	Value
Publication number	US-10513599-B2
Application number	US-201716072691-A
Country	US
Kind code	B2
Filing date	Aug 22, 2017
Priority date	Aug 23, 2016
Publication date	Dec 24, 2019
Grant date	Dec 24, 2019

Abstract

A cellulose ether acetate phthalate is provided, wherein the degree of substitution of phthalyl groups is from 0.02 to 0.25, the degree of neutralization of phthalyl groups is not more than 0.5, the degree of substitution of acetyl groups is from 0.02 to 0.40, and the total degree of substitution of phthalyl and acetyl groups is not more than 0.50. The cellulose ether acetate phthalate has a solubility in water of at least 2.0 weight percent at 2° C.

First claim

The invention claimed is:

1. A hydroxypropyl methyl cellulose acetate phthalate wherein
the degree of substitution of phthalyl groups is from 0.02 to 0.25, the degree of neutralization of phthalyl groups is not more than 0.5, wherein the degree of neutralization=[—C(O)—C 6 H 4 —COO − ]/[—C(O)—C 6 H 4 —COO − +—C(O)—C 6 H 4 —COOH], and
the degree of substitution of acetyl groups is from 0.07 to 0.25.

2. The hydroxypropyl methyl cellulose acetate phthalate of claim 1 having a solubility in water of at least 2.0 weight percent at 2° C.

3. The hydroxypropyl methyl cellulose acetate phthalate of claim 1 wherein the degree of substitution of phthalyl groups is from 0.04 to 0.15.

4. The hydroxypropyl methyl cellulose acetate phthalate of claim 1 wherein at least 85 wt. % of the hydroxypropyl methyl cellulose acetate phthalate is soluble in a mixture of 2.5 weight parts of the hydroxypropyl methyl cellulose acetate phthalate and 97.5 weight parts of water at 2° C.

5. A liquid composition comprising at least one hydroxypropyl methyl cellulose acetate phthalate of claim 1 dissolved in an aqueous liquid.

6. The liquid composition of claim 5 having a temperature of less than 15° C.

7. A liquid composition comprising at least one hydroxypropyl methyl cellulose acetate phthalate of claim 1 and an organic diluent.

8. A process for coating a dosage form comprising the step of contacting the liquid composition of claim 5 with the dosage form.

9. A process for the manufacture of capsule shells comprising the step of contacting the liquid composition of claim 5 with dipping pins.

10. A coated dosage form wherein the coating comprises at least one hydroxypropyl methyl cellulose acetate phthalate of claim 1 .

11. A polymeric capsule shell comprising at least one hydroxypropyl methyl cellulose acetate phthalate of claim 1 .

12. A capsule comprising a capsule shell of claim 11 and further comprising a drug or a nutritional or food supplement or a combination thereof.

13. A solid dispersion of at least one active ingredient in at least one hydroxypropyl methyl cellulose acetate phthalate of claim 1 .

14. A process for coating a dosage form comprising the step of contacting the liquid composition of claim 7 with the dosage form.

15. A process for the manufacture of capsule shells comprising the step of contacting the liquid composition of claim 7 with dipping pins.

Assignees

• Dow Global Technologies Llc
• Global Dow Tech Llc

Inventors

• Petermann Oliver

Classifications

• C08J3/03

  in aqueous media · CPC title

• C09D101/32

  Cellulose ether-esters · CPC title

• A61K9/4816

  Wall or shell material · CPC title

• C08L1/32 Primary

  Cellulose ether-esters · CPC title

• A61K9/4833

  Encapsulating processes; Filling of capsules (mechanical aspects A61J3/07) · CPC title