Method for producing acylsulfamoylbenzamides

Patent metadata

Field	Value
Publication number	US-10513490-B2
Application number	US-201615565067-A
Country	US
Kind code	B2
Filing date	Apr 4, 2016
Priority date	Apr 8, 2015
Publication date	Dec 24, 2019
Grant date	Dec 24, 2019

Abstract

The invention relates to a method for producing compounds of formula (Ia), in particular to a method for producing N-[4-(cyclopropylcarbamoyl)phenylsulfonyl]-2-methoxybenzamide.

First claim

The invention claimed is:

1. A process for preparing a compound of formula (Ia)

in which
R 1a to R 1e and R 2a to R 2d are each independently selected from the group consisting of hydrogen, halogen, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-haloalkyl, (C 1 -C 6 )-alkoxy, (C 3 -C 7 )-cycloalkoxy, (C 3 -C 7 )-cycloalkyl, (C 1 -C 6 )-alkylthio, (C 3 -C 7 )-cycloalkylthio, S(O) q —(C 1 -C 6 )-alkyl with q=0, 1 or 2, (C 1 -C 6 )-alkylcarbonyl, —CO-aryl, cyano and nitro or in which two adjacent R 1a to R 1e radicals in each case form a —O—CH 2 CH 2 — radical, and
R 3a is selected from the group consisting of hydrogen and the following radicals: (C 1 -C 6 )-alkyl, (C 1 -C 6 )-haloalkyl, (C 3 -C 7 )-cycloalkyl, (C 1 -C 6 )-alkoxy, (C 1 -C 6 )-alkylthio, (C 3 -C 7 )-cycloalkylthio, or —(CH 2 )-heterocyclyl, wherein these are each unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-haloalkyl, (C 1 -C 6 )-alkoxy, cyano and nitro, and
R 3b is selected from the group consisting of hydrogen and the following radicals: (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 1 -C 6 )-alkoxy, (C 2 -C 6 )-alkenyloxy, or —(CH 2 )-heterocyclyl, wherein these are each unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, (C 1 -C 4 )-alkoxy and (C 1 -C 4 )-alkylthio, or
R 3a and R 3b together with the connecting nitrogen atom form a 3- to 8-membered, saturated or unsaturated ring,
by reacting a compound of formula (II)

wherein R 1a to R 1e and R 2a to R 2d radicals are each as defined above, with an amine of the formula R 3a R 3b NH in which the R 3a and R 3b radicals are each as defined above, in aqueous solution, wherein the pH is regulated by
before adding the reactant of the formula (II), initially charging a portion of the amine of the formula R 3a R 3b NH in water at the start of the reaction to form an initial reaction charge, wherein the initial reaction charge does not include an alkali metal hydroxide solution, and
adding the remaining amount of the amine of the formula R 3a R 3b NH to the reaction mixture over the course of the reaction in one or more steps along with the reactant of the formula (II).

2. The process for preparing a compound of the formula (Ia) according to claim 1 , wherein R 1a to R 1e and R 2a to R 2d are independently selected from the group consisting of
hydrogen, fluorine, chlorine, bromine,
(C 1 -C 6 )-alkyl, wherein the alkyl radical is branched or unbranched and is unsubstituted or substituted by one or more substituents selected from the group consisting of (C 1 -C 4 )-alkoxy and (C 3 -C 7 )-cycloalkyl,
(C 1 -C 6 )-haloalkyl, wherein the the halogen substituents are selected from the group consisting of fluorine, chlorine, bromine and iodine,
(C 3 -C 7 )-cycloalkyl, wherein the cycloalkyl radical is unsubstituted or substituted by one or more substituents selected from the group consisting of (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl and (C 1 -C 4 )-alkoxy,
(C 1 -C 6 )-alkoxy, wherein the alkoxy radical is branched or unbranched and is unsubstituted or substituted by one or more substituents selected from the group consisting of (C 1 -C 4 )-alkoxy and (C 3 -C 7 )-cycloalkyl,
(C 3 -C 7 )-cycloalkoxy, wherein the cycloalkoxy radical is unsubstituted or substituted by one or more substituents selected from the group consisting of (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxy,
(C 1 -C 6 )-alkylthio, wherein the alkylthio radical is branched or unbranched and is unsubstituted or substituted by one or more substituents selected from the group consisting of (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxy, and
(C 3 -C 7 )-cycloalkylthio, wherein the cycloalkylthio radical is unsubstituted or substituted by one or more substituents selected from the group consisting of (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxy.

3. The process for preparing a compound of the formula (Ia) according to claim 2 , wherein R 1a is an unsubstituted (C 1 -C 4 )-alkoxy radical and R 1b to R 1e and R 2a to R 2d are each hydrogen.

4. The process for preparing a compound of the formula (Ia) according to claim 3 , wherein R 1a is methoxy (—O—CH 3 ), and R 1b to R 1e and R 2a to R 2d are each hydrogen.

5. The process for preparing a compound of the formula (Ia) according to claim 1 , wherein, in the formula (II),
R 1a is methoxy (—O—CH 3 ) and R 1b to R 1e and R 2a to R 2d are each hydrogen and, in the
amine of the formula R 3a R 3b NH, the R 1a radical is cyclopropyl and R 3b is hydrogen.

6. The process for preparing a compound of the formula (Ia) according to claim 1 , wherein the amine of the formula R 3a R 3b NH initially charged in water at the start of the reaction is present in sufficient amount to bring about adjustment of the pH of the initial reaction charge to no more than 11.5.

7. The process for preparing a compound of the formula (Ia) according to claim 6 , wherein the addition of the amount of the amine of the formula R 3a R 3b NH which is not initially charged at the start of the reaction is effected in several steps, such that the pH during the addition is in the range from 7 to 10.5.

8. The process for preparing a compound of the formula (Ia) according to claim 7 , wherein the addition of the amount of the amine of the formula R 3a R 3b NH which is not initially charged at the start of the reaction is effected in several steps, such that the pH during the addition is in the range from 9 to 10.5.

9. The process for preparing a compound of the formula (Ia) according to claim 6 , wherein after the formation of the initial reaction charge, a base selected from the group consisting of NaOH, KOH, Ca(OH) 2 and the group of the tertiary amines is added to the reaction mixture in order to prevent the pH from dropping below 8.

10. The process for preparing a compound of the formula (Ia) according to claim 9 , wherein the base is NaOH, and the addition of the base NaOH keeps the pH in the range from 9 to 10.

11. The process for preparing a compound of the formula (Ia) according to claim 1 , wherein the remaining amount of the amine of the formula R 3a R 3b NH is added to reaction mixture over the course of the reaction in one or more steps in parallel with the compound of the formula (II).

12. The process for preparing a compound of the formula (Ia) according to claim 1 , wherein the compound of the formula (II) is added by metered addition over a period of about 4 hours.

13. The process for preparing a compound of the formula (Ia) according to claim 9 , wherein the base is added to the reaction mixture on completion of addition of the amine of the formula R 3a R 3b NH and after addition of 20% of the compound of the formula (II), or on completion of addition of the compound of the formula (II).

14. The process for preparing a compound of the formula (Ia) according to claim 1 , wherein the remaining amount of the amine of the formula R 3a R 3b NH and the compound of the formula (II) are added to reaction mixture until 1:1 equivalents, based on the amount of amide chloride compound of the formula (II), is attained.

Assignees

• Bayer Cropscience Ag

Inventors

• Farida Taraneh
• Esser Michael
• Stakemeier Hubertus

Classifications

• C07C2601/02

  with a three-membered ring · CPC title

• C07C311/51 Primary

  Y being a hydrogen or a carbon atom · CPC title

• C07C303/40 Primary

  by reactions not involving the formation of sulfonamide groups · CPC title

• C07C303/42

  Separation; Purification; Stabilisation; Use of additives · CPC title