Method of predicting severity of multiple sclerosis

Patent metadata

Field	Value
Publication number	US-10506986-B2
Application number	US-201615282576-A
Country	US
Kind code	B2
Filing date	Sep 30, 2016
Priority date	Sep 30, 2016
Publication date	Dec 17, 2019
Grant date	Dec 17, 2019

Abstract

A method of predicting severity of multiple sclerosis (MS) in an animal in a vivarium is described. Animal activity data is collected at multiple times during the night. Sequential time regions of the night are identified as high-activity, activity-drop, or low-activity regions. Embodiments are described to quantify a drop, during the night, of an animal's activity level. These quantified activity-drop scalars for consecutive nights are accumulated in an animal health dataset. Then, an MS severity index function is applied to this dataset that, in response to the level of activity change and the speed of activity change, predicts or measures severity of MS in the animal. One embodiment quantifies an activity-drop by fitting straight-line curves through the data in the three nightly regions. Another embodiment uses a Fourier transform on a circle and a linear combination. Another embodiment compares areas under data curves in the regions. Animals may be housed in cages with other animals.

First claim

We claim:

1. A method of early detection of multiple sclerosis (MS) in a study animal in a vivarium comprising the steps of:
(aaa) placing the study animal in a cage in the vivarium;
(bbb) electronically observing one or more animal activities in real-time of the study animal using a combination of electronic cameras, infrared (IR) lighting of the study animals, and electronic hardware including computation and communication hardware;
(x) selecting a single “linear combination coefficient set” that generates a scalar linear combination value when applied responsively to a set of discreet transform values;
(y) selecting a “MS severity index function” whose input comprises an animal health dataset and whose output comprises a likelihood scalar representing a predicted severity of MS in the study animal;
(z) collecting an activity scalar of the study animal repeatedly and continually for a night: a set of “nightly activity data”;
(aa) computing a Fourier transform on a circle responsive to the nightly activity data, generating a set of discreet transform values;
(bb) applying the linear combination coefficient set responsively to the set of discreet transform values; wherein the resulting scalar linear combination value is a nightly activity value;
(cc) adding the nightly activity value into the animal health dataset; wherein the animal health dataset comprises the nightly activity values;
(dd) applying the MS severity index function to the animal health dataset;
(ee) iterating steps (z) through (dd) for sequential nights until a terminating condition is reached;
wherein the predicting severity of MS comprises the output of the MS severity index function applied to the animal health dataset of step (dd);
(ccc) terminating the study when the terminating condition is reached.

2. The method claim 1 wherein:
the MS severity index function further comprises an output that is an animal health dataset confidence value;
wherein in step (dd) the MS severity index function further generates an animal confidence value for the study animal; and
wherein the predicted severity of MS in the study animal further comprises the animal confidence values from steps (dd).

Assignees

• Vium Inc

Inventors

• Schaevitz Laura
• Ford Daniel J

Classifications

• A61B2503/42

  for laboratory research · CPC title

• A61B2503/40

  Animals · CPC title

• A61B5/4076

  Diagnosing or monitoring particular conditions of the nervous system · CPC title

• A61B5/7275 Primary

  Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor · CPC title

• G16H50/30

  for calculating health indices; for individual health risk assessment · CPC title