Application of the extrema distortion method to optimize control signals

Patent metadata

Field	Value
Publication number	US-10506983-B2
Application number	US-201715715113-A
Country	US
Kind code	B2
Filing date	Sep 25, 2017
Priority date	Mar 27, 2015
Publication date	Dec 17, 2019
Grant date	Dec 17, 2019

Abstract

A system is described that observes a signal from a subject of interest, converts the signal to an electrical representation, uses the electrical representation to compute a synthetic control signal, and applies the synthetic control signal to control some aspect of operation of the subject. The procedure used to generate the synthetic control signal involves subjecting the electrical representation of the observed signal to random noise, allowing the extrema of the electrical representation to move, and obtaining a converged solution as the synthetic control signal.

First claim

What is claimed is:

1. A system for controlling a signaling pathway in a subject of interest, comprising:
a sensor configured to observe a signal in the subject of interest, and configured to provide an electrical representation of said signal for further manipulation;
a module configured to accept as input said electrical representation of said signal for further manipulation;
a module configured to apply the Extrema Distortion Algorithm to said electrical representation of said signal, and configured to generate a synthetic control signal;
a module configured to provide said synthetic control signal as an output; and
a signal application module configured to receive said synthetic control signal and configured to apply said synthetic control signal to the subject of interest, wherein
said module configured to apply the Extrema Distortion Algorithm is a general purpose programmable computer which when operating under control of instructions recorded on a non-volatile medium is configured to perform the steps of said Extrema Distortion Algorithm, and
said Extrema Distortion Algorithm includes instructions recorded on said non-volatile medium that are configured to direct said general purpose computer to: (a) Select a randomly generated starting seed that successfully causes a state transition, (b) Find the extrema of the starting seed and measure the time interval between them, (c) Multiply each of the time intervals by a randomly generated number (e.g. with a Gaussian distribution), (d) Rescale the time of the synthetic stimulus to match the duration of the original stimulus, (e) Add to each peak a randomly generated number (e.g. with a Gaussian distribution), (f) Linearly transform all the data points between the extrema with the new extrema endpoints, (g) Test the distorted stimulus in the system, checking to see if it achieves pre-specified constraints, (h) Calculate the performance metric (e.g. L 2 -norm) of each of the neighboring stimuli, (i) Repeat steps (c)-(h) N times to produce N neighboring solutions based on the starting seed, (j) Choose the stimulus from among the neighboring solutions and the starting seed with the best performance, (k) Repeat steps (b)-(j) for a predetermined number of times M each iteration using the best stimuli found from the previous iteration as the new starting seed in step (b), and (l) After M iterations, output the stimulus with the best performance metric as the optimal stimulus.

2. The system for controlling a signaling pathway in a subject of interest of claim 1 , wherein said sensor configured to observe a signal is configured to provide said electrical representation in the form of an analog signal having an amplitude and a phase.

3. The system for controlling a signaling pathway in a subject of interest of claim 1 , wherein said sensor configured to observe a signal is configured to provide said electrical representation in the form of a plurality of discrete time based signals, each discrete signal having an amplitude and an identifier indicating the position of the signal in a time sequence.

4. The system for controlling a signaling pathway in a subject of interest of claim 1 , wherein said module configured to accept as input said electrical representation is a data acquisition module.

5. The system for controlling a signaling pathway in a subject of interest of claim 1 , wherein said module configured to provide said synthetic control signal as an output is a data acquisition module having a data output port.

Assignees

• Univ Massachusetts Medical School
• Univ Massachusetts

Inventors

• Paydarfar David
• Chang Joshua

Classifications

• A61M2021/0055

  with electric or electro-magnetic fields · CPC title

• A61B5/7235 Primary

  Details of waveform analysis (detecting specific parameters of the electrocardiograph cycle A61B5/349) · CPC title

• A61B5/7203

  for noise prevention, reduction or removal · CPC title

• A61B5/4094

  Diagnosing or monitoring seizure diseases, e.g. epilepsy · CPC title

• A61B5/04001

  Human Necessities · mapped topic