Delivery system

Patent metadata

Field	Value
Publication number	US-10500384-B2
Application number	US-98681211-A
Country	US
Kind code	B2
Filing date	Jan 7, 2011
Priority date	Jan 8, 2010
Publication date	Dec 10, 2019
Grant date	Dec 10, 2019

Abstract

Provided herein is a delivery system, including: (a) an optical sensor configured to detect data useful to create a map of a bodily surface; and (b) a printer operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the bodily surface based upon the data or map. Methods of forming a tissue on a bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing bodily surface data.

First claim

That which is claimed is:

1. A system for processing data of a bodily surface obtained from a three-dimensional optical detector to provide a path to a printer operatively associated to said optical detector, said system comprising:
means for interpreting data from said optical detector to form a model of the bodily surface;
means for transforming said model into a negative mold of the bodily surface, which mold is split into a plurality of Z-axis layers; and
means for overlaying each of said layers of the negative mold with a series of lines which represents coverage of the bodily surface, wherein said lines provide a path for control software to use to control the printer to deliver cells and/or compositions to said bodily surface in situ based upon said bodily surface data,
wherein the bodily surface data is wound surface data, and
wherein said data is updated in real-time during delivery of the cells and/or compositions by said printer.

2. The system of claim 1 , further comprising means for obtaining the data.

3. The system of claim 1 , wherein the data is skin wound surface data, and wherein the Z-axis layers correspond to tissue layers comprising dermis and/or epidermis layers of skin tissue.

4. The system of claim 1 , wherein the data are represented as an object including the Z axis layers, and
wherein each of the Z axis layers are represented by a grid which comprises the series of lines.

5. The system of claim 4 , further comprising means for parsing the object in a manner that incorporates locations of different cells and/or compositions to be printed by the printer.

6. The system of claim 1 , wherein said Z-axis layers correspond to one or more tissue layers.

7. A computer program product for processing data of a bodily surface obtained from a three-dimensional optical detector to provide a path to a printer operatively associated to said optical detector, the computer program product comprising a non-transitory computer readable medium having computer readable program code embodied therein, the computer readable program code comprising:
computer readable program code which interprets the data of the bodily surface from said optical detector to form a model of the bodily surface;
computer readable program code which transforms said model into a negative mold of the bodily surface, which mold is split into a plurality of Z-axis layers; and
computer readable program code which overlays each of said Z-axis layers of the negative mold with a series of lines which represents coverage of the bodily surface, wherein said lines provide a path for control software to use to control the printer to deliver cells and/or compositions to said bodily surface in situ based upon said data,
wherein the bodily surface data is wound surface data,
wherein said data is updated in real-time during delivery of the cells and/or compositions by said printer,
wherein the data are represented as an object including the layers,
wherein each of the layers are represented by a grid which comprises the series of lines, and
wherein the computer readable program code is configured to direct the printer to deliver cells to a first location of the bodily surface associated with a first piece of the grid representing the object while analyzing a second piece of the grid.

8. The computer program product of claim 7 , further comprising computer readable program code which parses the object in a manner that incorporates locations of different cells and/or compositions to be printed by the printer.

9. The computer program product of claim 7 , wherein said Z-axis layers correspond to one or more tissue layers.

10. The computer program product of claim 9 , wherein said bodily surface is a skin wound surface, and wherein the tissue layers comprise dermis and/or layers of skin tissue epidermis layers of skin tissue.

Assignees

• Yoo James J
• Atala Anthony
• Binder Kyle W
• Zhao Weixin
• Dice Dennis
• Xu Tao
• Univ Wake Forest Health Sciences

Inventors

• Yoo James J
• Atala Anthony
• Binder Kyle W
• Zhao Weixin
• Dice Dennis
• Xu Tao

Classifications

• A61M35/00 Primary

  Devices for applying media, e.g. remedies, on the human body (devices for handling toiletry or cosmetic substances A45D; absorbent pads, e.g. swabs, A61F13/15) · CPC title

• A61B5/445

  Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore · CPC title

• A61B5/0064 Primary

  Body surface scanning · CPC title

• A61M35/20 Primary

  Non-portable devices, e.g. spraying booths · CPC title

• A61B2017/3225

  with processing of harvested tissue · CPC title