Ceramic whole blood hollow fiber membrane filter medium and use thereof for separating blood plasma/serum from whole blood

Patent metadata

Field	Value
Publication number	US-10500328-B2
Application number	US-201514967860-A
Country	US
Kind code	B2
Filing date	Dec 14, 2015
Priority date	Jun 27, 2013
Publication date	Dec 10, 2019
Grant date	Dec 10, 2019

Abstract

A whole blood hollow fiber membrane filter medium is provided with a ceramic material having pores of a pore size that ensures permeability to blood plasma or serum and its molecular components while blood cells are retained. The whole blood hollow fiber membrane filter medium is used for separating blood plasma from whole blood, wherein the blood plasma preferably shows no hemolysis.

First claim

What is claimed is:

1. A whole blood hollow fiber membrane filter medium including
a ceramic material having pores of a pore size that ensures permeability to blood plasma or serum, but retains blood cells;
wherein hollow fibers of the whole blood hollow fiber membrane are tubular, having a radially inner surface in an interior of the hollow fiber, wherein the hollow fibers are ceramic hollow fibers
wherein the median pore diameter is in the range of from about 100 nm to about 1500 nm, or from about 150 nm to about 1300 nm, or from about 190 nm to about 1280 nm; and
wherein the whole blood hollow fiber membrane filter medium is coated on the radially inner surface of the surface of the hollow fiber membrane, the radially inner surface carrying at least one type of functional group from the carboxylate groups, and further carrying at least one type of functional groups selected from the group consisting of:
amino groups, silane groups, and any combinations thereof, and is coated with
a coating material further comprising bifunctional silanes with hydrolysable inorganic ethoxysilyl and fluoralkyl chains, or
fluoralkyl functional oligosiloxanes;

wherein the ceramic material comprises one or more ceramic materials selected from the group consisting of alumosilicate, magnesium silicate, and calcium titanate.

2. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the whole blood hollow fiber membrane filter medium consists of the ceramic material.

3. The whole blood hollow fiber membrane filter medium according to claim 2 , wherein
the pore size ensures permeability to blood plasma but retains blood cells.

4. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the pore size ensures permeability to blood plasma but retains blood cells.

5. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the pore size ensures permeability to electrolytes, lipid metabolism substances, markers, enzymes, substrates, proteins, pharmaceuticals, and vitamins.

6. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the whole blood hollow fiber membrane filter medium is a whole blood hollow fiber membrane cross-flow filter medium.

7. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the whole blood hollow fiber membrane filter medium is a whole blood hollow fiber membrane dead-end filter medium.

8. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the whole blood hollow fiber membrane filter medium has opposed ends and the opposed ends are open.

9. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the pore size allows molecules of less than about 8,000 kDa to pass.

10. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the median pore diameter is in a range of from about 190 nm to about 1,280 nm.

11. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the pores have a D10 pore diameter that is in a range of from about 150 nm to about 5,000 nm, and
the pores have a D90 pore diameter that is in the range of from about 30 nm to about 1,000 nm.

12. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the pores have an average pore diameter that is in a range of from about 100 nm to about 1,500 nm.

13. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the pores have a median pore diameter that is in a range of from about 100 nm to about 1,500 nm, and
wherein the pores have an average pore diameter that is in the range of from about 100 nm to about 1500 nm.

14. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the ceramic material comprises a silicon carbide.

15. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the ceramic material further comprises a metal oxide selected from the group consisting of aluminum oxide, silicon oxide, titanium oxide, and any combination thereof.

16. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the ceramic material further comprises at least one metal oxide selected from the group consisting of zirconium oxide and yttrium oxide.

17. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the ceramic material further comprises a sintered alpha aluminum oxide.

18. The whole blood hollow fiber membrane filter medium according to claim 17 , wherein
the ceramic material further comprises titanium dioxide,
wherein the titanium dioxide is present in an amount of 0.1 wt.-% to 0.5 wt.-% based on the total weight of the ceramic material.

19. The whole blood hollow fiber membrane filter medium according to claim 17 , wherein
a volumetric medium particle size of the sintered alpha aluminum oxide is from about 0.1 μm to about 2.0 μm.

20. The whole blood hollow fiber membrane filter medium according to claim 19 , wherein
the whole blood hollow fiber membrane filter medium has an outer diameter Do of from about 0.4 mm to about 3.0 mm.

21. The whole blood hollow fiber membrane filter medium according to claim 20 , wherein
the whole blood hollow fiber membrane filter medium has an inner diameter Di of from about 0.2 mm to about 2.0 mm, provided that the inner diameter Di is smaller than the outer diameter Do.

22. The whole blood hollow fiber membrane filter medium according to claim 21 , wherein
a ratio D0/Di of the outer diameter D o to the inner diameter Di, is in a range of from about 1.3 to about 2.0.

23. The whole blood hollow fiber membrane filter medium according to claim 21 , wherein
the outer diameter Do is from about 0.5 mm to about 2.0 mm and the inner diameter Di is from about 0.3 mm to about 1.3 mm.

24. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the whole blood hollow fiber membrane filter medium has a wall thickness of about 0.1 mm to about 1.0 mm.

25. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
a single hollow fiber membrane of the whole blood hollow fiber membrane filter medium comprises a length 0.5 cm to 8 cm length and a filtration area of from about 3 mm 2 to about 500 mm 2 .

26. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the whole blood hollow fiber membrane filter medium comprises a porosity from about 30% to about 70%.

27. The whole blood hollow fiber membrane filter medium according to claim 1 , wherein
the whole blood hollow fiber membrane filter medium is modified by coating or pre-wetting the whole blood hollow fiber membrane filter medium.

28. The whole blood hollow fiber membrane filter medium according to claim 27 , wherein
the whole blood hollow fiber membrane filter medium is pre-wetted with a salt solution, a solution of a blood stabilization agent, or a combination thereof.

29. The whole blood hollow fiber membrane filter medium according to claim 28 , wherein
the salt solution is a sodium chloride solution, and wherein the whole blood hollow fiber membrane is not dried after pre-wetting.

30. The whole blood hollow fiber membrane fil

Assignees

• Mann & Hummel Gmbh

Inventors

• Schuetz Steffen
• Rupp Heike
• Woerz Tobias
• Winkler Dagmar
• Woerz Kathrin
• Ehlen Frank
• Muenkel Karlheinz
• Stinzendoerfer Joachim

Classifications

• C08G77/00

  Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule · CPC title

• C08G77/04

  Polysiloxanes · CPC title

• A61M2205/33

  Controlling, regulating or measuring · CPC title

• A61M1/34 Primary

  Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration · CPC title

• B01D71/025

  Aluminium oxide · CPC title