Scaffold

Patent metadata

Field	Value
Publication number	US-10500310-B2
Application number	US-201415026830-A
Country	US
Kind code	B2
Filing date	Oct 2, 2014
Priority date	Oct 4, 2013
Publication date	Dec 10, 2019
Grant date	Dec 10, 2019

Abstract

A scaffold for tissue repair or wound dressing comprising: a material layer; a polymer fibre layer; and an adhesive component between the material layer and the polymer fibre layer, wherein the adhesive component comprises material having a lower melting temperature (Tm) than the material layer and the polymer fibre layer.

First claim

What is claimed is:

1. A scaffold for tissue repair or wound dressing comprising:
i. a material layer;
ii. two or more polymer fibre layers; and
iii. an adhesive component between each of the layers, wherein the adhesive component comprises a polymer having a lower melting temperature (Tm) than the material layer and the polymer fibre layers,
wherein the adhesive component between the polymer fibre layers is porous and comprises electrospun fibres that are substantially arranged in a grid pattern, and wherein the adhesive component between the material layer and the polymer fibre layer is non-porous.

2. The scaffold of claim 1 , wherein the scaffold is biodegradable.

3. The scaffold of claim 1 , wherein the polymer fibre layers, material layer and/or the adhesive component comprises or consists of electrospun polymer.

4. The scaffold of claim 1 , wherein the polymer fiber layers, material layer and/or the adhesive component comprises a thermoplastic electrospun polymer.

5. The scaffold of claim 3 , wherein the polymer comprises polydioxanone (PDO).

6. The scaffold of claim 1 , wherein, the material layer and/or polymer fibre layers have a melting temperature (Tm) of at least about 70° C.

7. The scaffold of claim 1 , wherein the material layer comprises or consists of a woven component.

8. The scaffold of claim 1 , wherein the polymer fibre layers and/or adhesive component are formed from fibres.

9. The scaffold of claim 1 , wherein the material layer and the polymer layers comprise substantially the same polymer.

10. The scaffold of claim 1 , wherein the adhesive component has a melting temperature (Tm) of less than about 70° C.

11. The scaffold of claim 1 , wherein the adhesive component comprises polycaprolactone (PCL).

12. The scaffold of claim 1 , wherein the scaffold comprises two or more layers of the material layer and/or polymer fibre layers.

13. The scaffold of claim 1 , wherein the scaffold comprises one or more agents dispersed or impregnated therein; or coated or seeded thereon.

14. The scaffold of claim 1 , wherein the scaffold has a tensile strength of at least 30 Mpa and/or a breaking strain of at least 25%.

15. The scaffold of claim 1 , wherein the scaffold comprises cells.

16. The scaffold of claim 1 , wherein the adhesive component comprises polymer fibres electrospun into a grid.

17. A method of treatment for a condition requiring the repair or replacement of damaged or degenerated tendon, ligament, bone and/or cartilage, comprising the use of the scaffold of claim 1 to repair, supplement or replace tissue.

18. A method of treatment for a wound, comprising the application of the scaffold of claim 1 to the wound.

Assignees

• Isis Innovation
• Univ Oxford Innovation Ltd

Inventors

• Hakimi Osnat
• Mouthuy Pierre-Alexis
• Baboldashti Nasim Zargar
• Carr Andrew

Classifications

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title

• A61L27/38 Primary

  containing added animal cells (organs or tissue containing native cells A61L27/36) · CPC title

• A61L27/18 Primary

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61F13/02

  Adhesive bandages or dressings · CPC title