Compositions and methods using IL-8 to improve milk production and reproductive health in mammals

Patent metadata

Field	Value
Publication number	US-10500253-B2
Application number	US-201615541126-A
Country	US
Kind code	B2
Filing date	Jan 5, 2016
Priority date	Jan 5, 2015
Publication date	Dec 10, 2019
Grant date	Dec 10, 2019

Abstract

The present disclosure provides compositions and methods for improving reproductive health of mammals and increasing milk production from female mammals. The methods involve administering an effective amount of IL-8 to a female mammal such that the reproductive health of the mammal is improved, or milk production from the mammal is increased, or the fat content of the milk is increased. In another aspect the disclosure includes prophylaxis and/or therapy of uterine conditions by administering IL-8 to a female mammal.

First claim

What is claimed is:

1. A method for inhibiting the development of puerperal metritis in a non-human female mammal comprising administering to the female mammal an effective amount of Interleukin-8 (IL-8), wherein the female mammal is within twenty weeks post parturition when the IL-8 is administered.

2. The method of claim 1 , wherein the administration of the IL-8 is an intrauterine administration or an intravaginal administration.

3. The method of claim 1 , wherein the female mammal is a member of a population of female mammals of the same species, the method further comprising administering the IL-8 to other members of the population within twenty weeks post parturition, such that inhibition of the development of puerperal metritis occurs in the other members subsequent to the administration.

4. The method of claim 1 , wherein the mammal is a bovine mammal.

5. The method of claim 4 , wherein the bovine mammal is a dairy cow.

Assignees

• Univ Cornell

Inventors

• Bicalho Rodrigo Carvalho

Classifications

• A61P15/14

  for lactation disorders, e.g. galactorrhoea · CPC title

• A61P3/00

  Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A23K20/147

  Polymeric derivatives, e.g. peptides or proteins · CPC title

• A61K38/2053 Primary

  IL-8 · CPC title