Compounds and methods for inducing chondrogenesis

Patent metadata

Field	Value
Publication number	US-10500210-B2
Application number	US-201414774673-A
Country	US
Kind code	B2
Filing date	Mar 13, 2014
Priority date	Mar 15, 2013
Publication date	Dec 10, 2019
Grant date	Dec 10, 2019

Abstract

Described herein are compounds and compositions for the amelioration of arthritis or joint injuries by inducing mesenchymal stem cells into chondrocytes.

First claim

What is claimed is:

1. A compound or a pharmaceutically acceptable salt, solvate, prodrug, ester, N-oxide, stereoisomer, or isomer thereof:

2. The compound of claim 1 ; wherein the compound is:

3. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt, solvate, prodrug, ester, N-oxide, stereoisomer, or isomer thereof, and a pharmaceutically acceptable excipient.

4. A method of ameliorating arthritis or joint injury in a mammal, the method comprising administering to a joint of the mammal a composition comprising a therapeutically effective amount of a compound of claim 1 , or pharmaceutically acceptable salt, solvate, prodrug, ester, N-oxide, stereoisomer, or isomer thereof.

Assignees

• Scripps Research Inst

Inventors

• Schultz Peter G
• Chatterjee Arnab K
• Zhu Shoutian
• Payette Joshua
• Yoon Hongchul
• Yang Baiyuan

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P29/02

  without antiinflammatory effect · CPC title

• A61P19/02

  for joint disorders, e.g. arthritis, arthrosis · CPC title

• C07C255/60

  at least one of the singly-bound nitrogen atoms being acylated · CPC title

• A61K31/194

  having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid · CPC title