Composition for skin whitening comprising amorphigeni as effective ingredient

Patent metadata

Field	Value
Publication number	US-10500146-B2
Application number	US-201615768609-A
Country	US
Kind code	B2
Filing date	Oct 13, 2016
Priority date	Oct 16, 2015
Publication date	Dec 10, 2019
Grant date	Dec 10, 2019

Abstract

A skin whitening composition includes amorphigeni or a salt thereof as an effective ingredient. Amorphigeni suppresses the expression of tyrosinase and induces autophagy on melanosomes. As such, it was confirmed that amorphigeni not only suppresses melanin production but also exhibits the effect of removing melanin previously produced by α-MSH (melanocyte-stimulating hormone). Accordingly, amorphigeni can be advantageously used as a functional material for skin whitening and skin lightening.

First claim

The invention claimed is:

1. A method of whitening the skin of a subject, the method comprising:
preparing a composition comprising amorphigeni represented by Chemical Formula 1 or a salt thereof as an effective ingredient:

and
applying the composition to the skin of the subject,
wherein the amorphigeni is prepared by a process comprising:
obtaining an extract from roots of Amorpha fruticosa;
concentrating the extract;
eluting the extract to obtain fractions; and
obtaining a fraction containing the amorphigeni in the largest amount.

2. The method of claim 1 , wherein the composition is a cosmetic composition which is a formulation selected from the group consisting of a solution, a suspension, an emulsion, a paste, a gel, a créme, a lotion, a powder, a soap, a surfactant-containing cleanser, an oil, a powder foundation, a foundation, a wax foundation and a spray.

3. The method of claim 1 , wherein the composition comprises the salt, and the salt is an acid addition salt formed with a free acid.

4. The method of claim 2 , wherein the formulation is the paste, the creme, or the gel; and the formulation composition comprises an animal fiber, a plant fiber, wax, paraffin, starch, tragacanth, a cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide, or a combination thereof as a carrier component.

5. The method of claim 2 , wherein the formulation is the powder or the spray; and the formulation comprises lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder or a combination thereof as a carrier component.

6. The method of claim 2 , wherein the formulation is the spray; and the formulation further comprises chlorofluorohydrocarbon, propane-butane, or dimethyl ether.

7. The method of claim 2 , wherein the formulation is the solution or the emulsion; and the formulation comprises a solvent, a solubilizing agent, or an emulsifying agent as a carrier component.

8. The method of claim 2 , wherein the formulation is the suspension; and the formulation comprises a liquid phase diluent, a suspending agent, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar, or tragacanth as a carrier component.

9. The method of claim 2 , wherein the formulation is the surfactant-containing cleanser; and the formulation comprises aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfonsuccinic acid monoester, acethionate, an imidazoilum derivative, methyl taurate, sarcosinate, fatty acid amide ether sulfate, alkylamidobetain, aliphatic alcohol, fatty acid glyceride, fatty acid diethanolamide, plant oil, a linolin derivative, or ethoxylated glycerol fatty acid ester.

10. The method of claim 2 , wherein the formulation further comprises an additional skin whitening active component selected from the group consisting of kojic acid, albutin, ascorbic acid, hydroquinone, resorcinol, cycloalkanone, methylene dioxyphenylalkanol, 2,7-dinitroindazole, a bearberry extract, a rice extract, a liquorice extract, and a derivative thereof.

11. The method of claim 1 , wherein the composition further comprises a vehicle including a fluorescent material, a bactericidal agent, a hydrotrope, a moisturizing agent, an aroma, an aromatic carrier, a protein, a solubilizing agent, a sugar derivative, a sunshine blocking agent, a vitamin, a plant extract, or a combination thereof.

12. The method of claim 1 , wherein the composition is a pharmaceutical composition that is a formulation selected from the group consisting of an injection solution, a créme, a patch, a spray, an ointment, a hard solid, a lotion, a liniment, a paste, and a cataplasma.

13. The method of claim 12 , wherein the pharmaceutical composition further comprises a pharmaceutically acceptable carrier selected from the group consisting of lactose, dextrose, sucrose, sorbitol, mannitol, starch, acacia gum, calcium phosphate, alginate, gelatin, calcium silicate, microcrystalline cellulose, polyvinyl pyrrolidone, cellulose, water, syrup, methyl cellulose, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, mineral oil, and a combination thereof.

14. The method of claim 12 , wherein the pharmaceutical composition further comprises a lubricating agent, a humidifying agent, a sweetening agent, a flavoring agent, an emulsifying agent, a suspending agent, a preservative, or a combination thereof.

15. The method of claim 1 , wherein the subject has a melanin hyperpigmentation disorder.

16. The method of claim 15 , wherein the melanin hyperpigmentation disorder is freckles, senile spots, chloasma, small brown spots, brown or black moles, sunshine pigment spots, cyanic melisma, hyperpigmentation after drug use, gravidic chloasma, or hyperpigmentation after inflammation caused by lesions or skin inflammation.

17. The method of claim 15 , wherein the composition is prepared as any one formulation selected from an injection solution, créme, a patch, a spray, an ointment, a hard solid, a lotion, a liniment, a paste, and a cataplasma.

18. The method of claim 15 , wherein the composition is a pharmaceutical composition comprising a pharmaceutical carrier.

19. A method of whitening the skin of a subject, the method comprising:
preparing an isolated amorphigeni represented by Chemical Formula 1 or a salt thereof:

preparing a composition comprising the isolated amorphigeni; and
applying the composition to the skin of the subject.

20. The method of claim 19 , wherein the isolated amorphigenin has a purity of at least 70%.

Assignees

• Nat Univ Gyeongsang Iacf

Inventors

• Kim Kwang Dong
• Yoo Ji Yun
• Park Soojong
• Oh Sangseok
• Kim Dae Wook
• Park Ki Hun
• Lee Kiwon

Classifications

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61P17/00

  Drugs for dermatological disorders · CPC title

• A61K8/9783

  Angiosperms [Magnoliophyta] · CPC title

• A61K9/0014

  Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00) · CPC title