Systems and methods for formulating radioactive liquids

Patent metadata

Field	Value
Publication number	US-10497485-B2
Application number	US-201615368265-A
Country	US
Kind code	B2
Filing date	Dec 2, 2016
Priority date	Dec 2, 2016
Publication date	Dec 3, 2019
Grant date	Dec 3, 2019

Abstract

Systems and methods for formulating a radioactive liquid using a disposable container are described. The disposable container includes a flexible sidewall defining an interior space for containing the radioactive liquid during formulation. The flexible sidewall is constructed of sterile, pyrogen-free material to prevent contamination of the radioactive liquid. The flexible sidewall includes a first portion and a second portion. The disposable container also includes an access port and a dispense port. The access port is defined by the first portion of the flexible sidewall to provide access to the interior space. The dispense port is defined by the second portion of the flexible sidewall for the radioactive liquid within the interior space to be dispensed through.

First claim

What is claimed is:

1. A disposable container for use in formulating a radioactive liquid, the container including:
a flexible sidewall defining an interior space for containing the radioactive liquid during formulation, the flexible sidewall being constructed of sterile, pyrogen-free material to prevent contamination of the radioactive liquid, the flexible sidewall including a first portion and a second portion;
an access port defined by the first portion of the flexible sidewall to provide access to the interior space;
a dispense port defined by the second portion of the flexible sidewall for the radioactive liquid within the interior space to be dispensed through; and
circulation ports defined by the flexible sidewall and connectable to a circulation tube to allow circulation of the radioactive liquid within the interior space.

2. The disposable container of claim 1 , wherein the second portion is at least partially funnel-shaped to direct the radioactive liquid towards the dispense port.

3. The disposable container of claim 2 further comprising angled seams that form the funnel shape.

4. The disposable container of claim 1 further comprising a cap to close the access port.

5. The disposable container of claim 1 , wherein the circulation ports are defined by the second portion of the flexible sidewall.

6. The disposable container of claim 1 , wherein the first portion is configured to receive connectors, the disposable container arranged to be suspended from the connectors such that the first portion is above the second portion.

7. The disposable container of claim 1 further comprising eyelets for securing the disposable container to a positioning device, wherein the sidewall is sealed adjacent the eyelets to prevent the radioactive liquid from exiting the interior space through the eyelets.

8. A system for formulating a radioactive liquid, the system comprising:
a nuclear radiation containment chamber including an enclosure constructed of a nuclear radiation shielding material;
a disposable container including a flexible sidewall, the flexible sidewall defining an interior space for containing the radioactive liquid during formulation;
a positioning device positioned within an interior of the enclosure, the positioning device including:
a support configured to support the disposable container on the positioning device; and
an actuator operatively connected to the support and configured to rotate the support, the actuator including a motor; and

a dispense pump connected to the disposable container in fluid communication with the interior space to dispense the radioactive liquid from the interior space.

9. The system of claim 8 further comprising a circulation pump connected to the disposable container for circulating the radioactive liquid.

10. The system of claim 8 , wherein the flexible sidewall includes a first portion and a second portion, the disposable container including an access port defined by the first portion, a dispense port defined by the second portion, and circulation ports defined by the second portion.

11. The system of claim 8 further comprising a controller and an interface connected to the actuator to control the position of the disposable container.

12. The system of claim 11 , wherein the controller is configured to rotate the disposable container such that liquid flows towards a dispense port when the dispense pump dispenses the radioactive liquid.

13. The system of claim 8 , wherein the support comprises a table, the disposable container being connected to the table by fasteners extending through a first portion of the flexible sidewall.

14. The system of claim 8 further comprising tubes extending between the disposable container and the dispense pump.

15. A method of formulating radioactive liquid contained within a disposable container, the method comprising:
connecting the disposable container to a positioning device;
rotating an actuator of the positioning device to position the disposable container in a first position, the actuator including a motor;
formulating the radioactive liquid within an interior space of the disposable container while the disposable container is in the first position;
rotating the actuator of the positioning device to position the disposable container in a second position; and
dispensing the liquid from the disposable container using a dispense pump, wherein the radioactive liquid is directed towards a dispense port of the disposable container when the disposable container is in the second position.

16. The method of claim 15 further comprising opening an access port of the disposable container to access the interior space while the disposable container is in the first position.

17. The method of claim 15 further comprising circulating the radioactive liquid using a circulation pump in fluid communication with the disposable container.

18. The method of claim 15 , wherein formulating the radioactive liquid includes diluting the liquid, the method further comprising extracting a sample of the liquid, adjusting a pH of the liquid, and homogeneously mixing the liquid.

19. The method of claim 15 , wherein rotating an actuator of the positioning device to position the disposable container in a first position comprises positioning the disposable container at an angle relative to a horizontal plane.

20. The method of claim 19 , wherein the angle is in a range of about −5 degrees to about 90 degrees.

Assignees

• Curium Us Llc

Inventors

• Graves Kevin B
• Petrofsky Bryan S
• Verma Sumit
• Schmitz John
• Bushman Greg
• Gurley Iv Jesse
• Hibbeln Paul

Classifications

• G21F5/00 Primary

  Transportable or portable shielded containers · CPC title

• A61J1/1475

  Inlet or outlet ports · CPC title

• A61J1/10

  Bag-type containers · CPC title

• B65D83/00

  Containers or packages with special means for dispensing contents (dispensing means incorporated in closures B65D47/00) · CPC title

• B65D85/82

  for poisons · CPC title