Method of preventing or treating oral infections using zirconia autopolymerizable resins

Patent metadata

Field	Value
Publication number	US-10494532-B2
Application number	US-201715840267-A
Country	US
Kind code	B2
Filing date	Dec 13, 2017
Priority date	May 9, 2017
Publication date	Dec 3, 2019
Grant date	Dec 3, 2019

Abstract

A method of preventing or treating an oral disease by reducing adhesion of microorganisms, e.g. Candida albicans , to dental appliances fabricated and/or repaired by an autopolymerizing acrylic reinforcement resin comprising zirconium dioxide nanoparticles.

First claim

The invention claimed is:

1. A method of preventing or treating an oral infection in a subject by preventing or reducing adhesion of a microorganism to a repaired acrylic dental appliance worn by the subject, the method comprising:
dispersing a nanocomposite powder in a monomer liquid comprising methyl methacrylate thereby forming a reinforcement resin, the nanocomposite powder comprising:
an acrylic polymer powder comprising polymethyl methacrylate; and
zirconium dioxide nanoparticles;

applying and packing the reinforcement resin in excess to a repair gap of an acrylic dental appliance; and
autopolymerizing the reinforcement resin thereby forming the repaired acrylic dental appliance.

2. The method of claim 1 , wherein the microorganism is selected from the group consisting of bacteria and fungi.

3. The method of claim 1 , wherein the microorganism is a fungus selected from the Candida species.

4. The method of claim 1 , wherein the nanocomposite powder comprises 1-10 wt % zirconium dioxide nanoparticles relative to a total weight of the nanocomposite powder.

5. The method of claim 1 , wherein the zirconium dioxide nanoparticles have an average size of 20-110 nm, and an average surface area of 5-15 m 2 /g.

6. The method of claim 1 , wherein the reinforcement resin has a nanocomposite powder to monomer liquid mass ratio in a range of 0.5:1 to 3:1.

7. The method of claim 1 , wherein the autopolymerizing is performed at a temperature of 20-50° C., and a pressure of 10-50 psi.

8. The method of claim 1 , further comprising treating the zirconium dioxide nanoparticles with a silane coupling reagent prior to the dispersing.

9. The method of claim 1 , wherein reduced adhesion of the microorganism to the repaired acrylic dental appliance is measurable by a microbial count.

10. The method of claim 1 , wherein the acrylic dental appliance is a denture.

11. The method of claim 1 , wherein the oral infection is denture stomatitis.

Assignees

• Univ Imam Abdulrahman Bin Faisal
• Imam Abulrahman Bin Faisal Univ

Inventors

• Gad Mohammed Moustafa Ahmed
• Al-Thobity Ahmad M
• Shahin Suliman S

Classifications

• C08K2003/2244

  of zirconium · CPC title

• C08K3/22

  of metals · CPC title

• A61K6/35

  Preparations for stabilising dentures in the mouth · CPC title

• A61K6/17

  Particle size · CPC title

• A61K6/889

  Polycarboxylate cements; Glass ionomer cements · CPC title