Method of treating cancer with a two-component anti-cancer composition

Patent metadata

Field	Value
Publication number	US-10494392-B2
Application number	US-201916404355-A
Country	US
Kind code	B2
Filing date	May 6, 2019
Priority date	Apr 17, 2017
Publication date	Dec 3, 2019
Grant date	Dec 3, 2019

Abstract

Gold(I) complexes and gold(I) dithiocarbamate polymers as anticancer therapeutics. The Au(I) ion within the gold(I) complexes is coordinated to two phosphine ligands. The repeating unit formed by Au(I) ion coordinating to dithiocarbamate ligands are connected by Au(I)—Au(I) interactions within the gold(I) dithiocarbamate polymers. Also disclosed are methods of synthesis, pharmaceutical compositions incorporating the gold(I) complexes, pharmaceutical compositions incorporating the gold(I) dithiocarbamate polymers, and methods of treating cancer.

First claim

The invention claimed is:

1. A method of treating cancer, comprising:
administering a gold/cis-platin composition to a subject in need of therapy of at least one of lung cancer, colon cancer, and breast cancer,
wherein the gold/cis-platin composition comprises cis-platin and a gold(I) complex of formula (I):

or a salt thereof, a tautomer thereof, a stereoisomer thereof, or a mixture thereof,
wherein R 1 , R 2 , R 3 , and R 4 are independently selected from the group consisting, of a hydrogen, an optionally substituted alkyl, an optionally substituted alkoxy, and a nitro;
R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , and R 12 are independently selected from the group consisting of a hydrogen, an optionally substituted alkyl; and
X is an anion.

2. The method of claim 1 , wherein the cancer is resistant to cisplatin.

3. The method of claim 1 , wherein 1-300 mg/kg of gold(I) complex of formula (I) is administered per body weight of the subject.

Assignees

• Univ King Fahd Pet & Minerals

Inventors

• Isab Anvarhusein A
• Altaf Muhammad
• Seliman Adam Ahmed Abdallah

Classifications

• C07F1/12

  Gold compounds · CPC title

• C07F9/5045 Primary

  Complexes or chelates of phosphines with metallic compounds or metals · CPC title

• A61K31/80

  Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795 · CPC title

• C08G79/00

  Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon {with or without the latter elements in the main chain of the macromolecule} · CPC title