Compounds that inhibit mcl-1 protein
US-2017088560-A1 · Mar 30, 2017 · US
Compounds that inhibit Mcl-1 protein
US10494381B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10494381-B2 |
| Application number | US-201816123030-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 6, 2018 |
| Priority date | Aug 29, 2014 |
| Publication date | Dec 3, 2019 |
| Grant date | Dec 3, 2019 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
Provided herein are compounds that are useful intermediates that may used to synthesize myeloid cell leukemia 1 protein (Mcl-1) inhibitors. Also provided are Mcl-1 inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound, wherein the compound has a formula selected from one of the following: 2. The compound of claim 1 , wherein the compound has the formula: 3. The compound of claim 1 , wherein the compound has the formula: 4. The compound of claim 1 , wherein the compound has the formula: 5. A compound, wherein the compound has a formula selected from one of the following: 6. The compound of claim 5 , wherein the compound has the formula: 7. The compound of claim 5 , wherein the compound has the formula: 8. The compound of claim 5 , wherein the compound has the formula: 9. The compound of claim 5 , wherein the compound has the formula: 10. The compound of claim 5 , wherein the compound has the formula: 11. The compound of claim 5 , wherein the compound has the formula: 12. The compound of claim 5 , wherein the compound has the formula: 13. The compound of claim 5 , wherein the compound has the formula:
Assignees
Inventors
Classifications
specific for leukemia · CPC title
Antineoplastic agents · CPC title
- C07D513/08Primary
Bridged systems · CPC title
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms (4-oxa-1-azabicyclo [3.2.0] heptanes, e.g. oxapenicillins C07D503/00; 5-oxa-1-azabicyclo [4.2.0] octanes, e.g. oxacephalosporins C07D505/00; analogues thereof having ring oxygen atoms in other position C07D507/00) · CPC title
- C07D513/10Primary
Spiro-condensed systems · CPC title
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Frequently asked questions
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- What does patent US10494381B2 cover?
- Provided herein are compounds that are useful intermediates that may used to synthesize myeloid cell leukemia 1 protein (Mcl-1) inhibitors. Also provided are Mcl-1 inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts t…
- Who is the assignee on this patent?
- Amgen Inc
- What technology area does this patent fall under?
- Primary CPC classification C07D513/08. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 03 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 4 related publications on this page (citations in our corpus or others sharing the same primary CPC).