Processes for the preparation of uracil derivatives
US-9868706-B2 · Jan 16, 2018 · US
Processes for the preparation of uracil derivatives
US10494347B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10494347-B2 |
| Application number | US-201715833513-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 6, 2017 |
| Priority date | Nov 7, 2007 |
| Publication date | Dec 3, 2019 |
| Grant date | Dec 3, 2019 |
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- Title
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- Abstract
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Abstract
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The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound of structure (VII) wherein: R 2a and R 2b are the same or different and independently halogen, trifluoromethyl, cyano or —SO 2 CH 3 ; and R 3 is hydrogen or methyl. 2. The compound of claim 1 wherein R 2a is F and R 2b is —CF 3 . 3. The compound of claim 2 wherein R 3 is hydrogen. 4. A compound of structure (VII) wherein: R 2a and R 2b are different and independently hydrogen, halogen, trifluoromethyl, cyano or —SO 2 CH 3 ; and R 3 is hydrogen or methyl. 5. The compound of claim 4 wherein R 2a is F. 6. The compound of claim 5 wherein R 3 is methyl. 7. The compound of claim 4 wherein R 2b is −CF 3. 8. The compound of claim 7 wherein R 3 is methyl.
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Classifications
with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil · CPC title
Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives · CPC title
- C07D239/54Primary
as doubly bound oxygen atoms or as unsubstituted hydroxy radicals · CPC title
with organic macromolecular compounds · CPC title
resulting in pure drug agglomerate optionally containing up to 5% of excipient · CPC title
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Frequently asked questions
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- What does patent US10494347B2 cover?
- The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
- Who is the assignee on this patent?
- Neurocrine Biosciences Inc
- What technology area does this patent fall under?
- Primary CPC classification C07D239/54. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 03 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).