(22E)-2-methylene-26,27-cyclo-22-dehydro-1α-hydroxy-19-norvitamin D3 derivatives
US-9834512-B2 · Dec 5, 2017 · US
(20S)-1-α,25-dihydroxy-24,24-difluoro-19-nor-vitamin D3 analogs and their pharmaceutical uses
US10494337B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10494337-B2 |
| Application number | US-201615165884-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 26, 2016 |
| Priority date | May 26, 2015 |
| Publication date | Dec 3, 2019 |
| Grant date | Dec 3, 2019 |
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Abstract
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Disclosed are 1α,25-dihydroxy-24,24-difluoro-2-methylene-19-nor-vitamin D analogs and their pharmaceutical uses. These new vitamin D analogs are 19-nor-vitamin D analogs having two fluorine atom substitutions at the 24 position (C-24) in the side chain and optionally having a 2-methylene substituent.
First claim
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We claim: 1. A compound having the formula: where X 1 , X 2 , and X 3 , which may be the same or different, are each independently selected from hydrogen or a hydroxy-protecting group. 2. The compound of claim 1 wherein X 1 is hydrogen. 3. The compound of claim 1 wherein X 2 is hydrogen. 4. The compound of claim 1 wherein X 1 and X 2 are both t-butyldimethylsilyl. 5. The compound of claim 1 wherein X 3 is hydrogen. 6. The compound of claim 1 wherein X 3 is triethylsilyl. 7. The compound of claim 1 having a formula: 8. A pharmaceutical composition containing an effective amount of the compound of claim 1 or a pharmaceutical salt thereof together with a pharmaceutically acceptable excipient. 9. The pharmaceutical composition of claim 8 wherein said effective amount comprises about 1.0 μg to about 1000.0 μg per gram of the composition.
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Frequently asked questions
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- What does patent US10494337B2 cover?
- Disclosed are 1α,25-dihydroxy-24,24-difluoro-2-methylene-19-nor-vitamin D analogs and their pharmaceutical uses. These new vitamin D analogs are 19-nor-vitamin D analogs having two fluorine atom substitutions at the 24 position (C-24) in the side chain and optionally having a 2-methylene substituent.
- Who is the assignee on this patent?
- Wisconsin Alumni Res Found
- What technology area does this patent fall under?
- Primary CPC classification C07C401/00. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 03 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).