Thermal ablation system

Patent metadata

Field	Value
Publication number	US-10493301-B2
Application number	US-201515316888-A
Country	US
Kind code	B2
Filing date	Jun 4, 2015
Priority date	Jun 20, 2014
Publication date	Dec 3, 2019
Grant date	Dec 3, 2019

Abstract

A thermal ablation includes a thermal ablation apparatus configured to perform thermal ablation on a targeted tissue according to plan data of a treatment during a therapy mode of the thermal ablation system. An MR apparatus is configured to perform T2* weighted MR imaging of the targeted tissue to assess a therapeutic response of the thermal ablation during an assessment mode of the thermal ablation system. A control apparatus is configured to switch the thermal ablation system between the therapy mode and the assessment mode. The thermal ablation apparatus is activated to perform the thermal ablation in the therapy mode. The thermal ablation apparatus is deactivated to terminate the thermal ablation and the MR apparatus is activated to perform the T2* weighted MR imaging in the assessment mode.

First claim

The invention claimed is:

1. A thermal ablation system comprising:
a thermal ablation apparatus configured to perform thermal ablation on a targeted tissue in a patient according to plan data of a treatment during a therapy mode;
a magnetic resonance (MR) apparatus configured to acquire a T2* weighted MR image without injection of a contrast agent of the targeted tissue to visualize an ablated volume due to the thermal ablation on the T2* weighted MR image during an assessment mode of the thermal ablation system; and
a control apparatus or computer processor coupled to the thermal ablation apparatus and the MR apparatus and configured to switch the thermal ablation system between the therapy mode and the assessment mode, wherein the thermal ablation apparatus is activated to perform the thermal ablation in the therapy mode, and wherein the thermal ablation apparatus is deactivated to terminate the thermal ablation and the MR apparatus is activated to acquire the T2* weighted MR image without contrast agent injection in the assessment mode.

2. The thermal ablation system of claim 1 , wherein the thermal ablation apparatus includes a high intensity focused ultrasound transducer disposed exterior to the patient and is configured to ablate the targeted tissue by transmitting high intensity ultrasound radiation focused on the targeted tissue through the skin of the patient.

3. The thermal ablation system of claim 1 , wherein the control apparatus or computer processor is further configured to modify the plan data of the treatment plan based on the assessed ablated volume of the thermal ablation during the assessment mode.

4. The thermal ablation system of claim 1 , wherein the control apparatus or computer processor is further configured to switch the thermal ablation system from the therapy mode to the assessment mode subsequent to completion of the treatment in accordance with the plan data.

5. The thermal ablation system of claim 1 , wherein the control apparatus or computer processor is further configured to switch the thermal ablation system between the therapy mode and the assessment mode during the treatment to assess the ablated volume of the thermal ablation in a real-time manner and modify the plan data of the treatment plan based on the assessed ablated volume.

6. The thermal ablation system of claim 1 , wherein the MR apparatus is further configured to guide the thermal ablation during the therapy mode of the thermal ablation system.

7. The thermal ablation system of claim 1 , wherein a dark line margin of the ablated volume is visible on the T2* weighted MR image acquired without contrast agent injection.

8. The thermal ablation system of claim 1 , further comprising:
a graphical user interface configured to display the T2* weighted MR image acquired without contrast agent injection to visualize the ablated volume of the thermal ablation.

9. The thermal ablation system of claim 1 , wherein the T2* weighted MR image acquired without contrast agent injection includes a dark line margin around the ablated volume and wherein the control apparatus or computer processor is further configured to recognize the dark line margin in the assessment mode.

10. A method for controlling a thermal ablation system which is configured to operate in a therapy mode and an assessment mode, wherein thermal ablation is activated to be performed on a target tissue according to plan data of a treatment during the therapy mode and is deactivated during the assessment mode, the method comprising:
performing without injection of a contrast agent of a T2* weighted magnetic resonance (MR) imaging of the targeted tissue to acquire a T2* weighted MR image without contrast agent during the assessment mode of the thermal ablation system;
visualizing an ablated volume of the thermal ablation on the T2* weighted MR image without contrast agent during the assessment mode of the thermal ablation system;
recognizing a dark line margin of the ablated volume in the T2* weighted MR image without contrast agent injection;
modifying the plan data of the treatment based on an assessment of the dark line margin of the ablated volume of the thermal ablation; and
after modifying the plan data of the treatment, performing further ablation of the target tissue based on the modified plan data of the treatment.

11. The method of claim 10 , wherein the targeted tissue is uterine fibroids.

12. The method of claim 10 , further comprising:
modifying the plan data of the treatment plan based on the assessed ablated volume of the thermal ablation during the assessment mode.

13. The method of claim 10 , further comprising switching the thermal ablation system from the therapy mode to the assessment mode upon completion of the treatment in accordance with the plan data.

14. The method of claim 10 , further comprising:
switching the thermal ablation system from the therapy mode to the assessment mode during the treatment to assess the ablated volume of the thermal ablation in a real-time manner.

15. A method for thermal ablation of tissue with a thermal ablation system, comprising:
thermally ablating tissue with the thermal ablation system in accordance with treatment plan data from a treatment plan memory;
performing without injection of a contrast agent a T2* weighted magnetic resonance (MR) imaging of a region comprising tissue treated with a thermal ablation system, a boundary between necrotic tissue and non-necrotic tissue in the region inducing an inhomogeneity of a magnetic field applied during the MR imaging;
reconstructing a contrast agent free T2* weighted MR image of the region, the magnetic field inhomogeneity resulting in a dark line margin between the necrotic and non-necrotic tissue;
based on an assessment of the dark line margin, modifying the treatment plan data; and
performing further thermal ablation in accordance with the modified treatment plan data.

16. A computer program product comprising machine executable instructions stored on a non-transitory computer readable medium to be executed by a microprocessor of a thermal ablation system, wherein the execution of the machine executable instructions causes the microprocessor to control thermal ablation on a targeted tissue according to plan data of a treatment during a therapy mode of the thermal ablation system;
acquire a T2* weighted MR image without injection of a contrast agent of the targeted tissue during an assessment mode of the thermal ablation system;
visualizing an ablated volume of the thermal ablation on the T2* weighted MR image during the assessment mode of the thermal ablation system; and
switch the thermal ablation system between the therapy mode and the assessment mode, wherein the thermal ablation is activated and the T2* weighted MR imaging without contrast agent injection is deactivated in the therapy mode, and wherein the thermal ablation is deactivated and the T2* weighted MR imaging without contrast agent injection is activated in the assessment mode.

Assignees

• Koninklijke Philips Nv

Inventors

• Wei Juan
• Zhang Jianhua

Classifications

• A61B5/0036 Primary

  including treatment, e.g., using an implantable medical device, ablating, ventilating · CPC title

• A61N7/02 Primary

  Localised ultrasound hyperthermia · CPC title

• A61B2034/104

  Modelling the effect of the tool, e.g. the effect of an implanted prosthesis or for predicting the effect of ablation or burring · CPC title

• A61B34/10

  Computer-aided planning, simulation or modelling of surgical operations · CPC title

• A61N2007/0086

  Beam steering · CPC title