Small molecule transport device with anti-condensation filler for drug delivery or waste removal

Patent metadata

Field	Value
Publication number	US-10492945-B2
Application number	US-201815985468-A
Country	US
Kind code	B2
Filing date	May 21, 2018
Priority date	May 22, 2017
Publication date	Dec 3, 2019
Grant date	Dec 3, 2019

Abstract

An implantable medical device is described. The implantable medical device includes an anti-condensation filler that is highly permeable to a predetermined class of small molecules, such as oxygen. The implantable medical device includes a small molecule discharge bag that is permeable to the small molecule, and a cannula that connects an interior of the small discharge bag to the anti-condensation filler. In operation, small molecules are collected and transported through the anti-condensation filler to the cannula for diffusion through the small molecule discharge bag. Even when this device is implanted in a high humidity and temperature gradient environment, the anti-condensation filler prevents condensation, such as water condensation.

First claim

What is claimed is:

1. A biocompatible, implantable medical device comprising:
a collection and transport element comprising an anti-condensation filler, a permeable coating, and a nonpermeable coating, wherein:
the anti-condensation filler is permeable to a predetermined class of small molecules and comprises a base and an elongated body extending from the base,
the permeable coating is permeable to the small molecules and is over at least a portion of an external surface of the base,
the nonpermeable coating is nonpermeable to the small molecules and is over at least a portion of an external surface of the elongated body;

a cannula comprising a lumen; and
a small molecule discharge bag comprising an interior, wherein at least a portion of the small molecule discharge bag is permeable to the small molecules.

2. The biocompatible, implantable medical device of claim 1 , wherein the lumen of the cannula connects the elongated body of the anti-condensation filler with the interior of the small molecule discharge bag, wherein the anti-condensation filler comprises a nano-porous material, and wherein the predetermined class of small molecules comprises oxygen.

3. The biocompatible, implantable medical device of claim 2 , wherein the nano-porous material comprises a nano-porous glass that is hydrophobized based on silanization, wherein the base and the elongated body are integrally formed with the nano-porous glass.

4. The biocompatible, implantable medical device of claim 3 , wherein the nano-porous glass comprises pores having an average width determined based on the Kelvin Equation.

5. The biocompatible, implantable medical device of claim 4 , wherein the average width is within a range of four to twenty nanometers, and wherein a density of the pores is in the range of twenty to fifty percent.

6. The biocompatible, implantable medical device of claim 1 , wherein the base is substantially cylindrical and has a first height and a first diameter, wherein the elongated body is substantially cylindrical and has a second height and a second diameter, and wherein the first height is smaller than the second height and the first diameter is larger than the second diameter.

7. The biocompatible, implantable medical device of claim 6 , wherein the first height is between 0.1 and two millimeters, and wherein the first diameter is between one and fifteen millimeters.

8. The biocompatible, implantable medical device of claim 6 , wherein the second height is between one and twenty-five millimeters, and wherein the second diameter is between 0.05 and three millimeters.

9. The biocompatible, implantable medical device of claim 1 , wherein the base and the elongated body are integrally formed in substantially a T-shaped tack, wherein the base corresponds to a cylindrical head of the T-shaped tack, and wherein the elongated body corresponds to a cylindrical shaft of the T-shaped tack.

10. The biocompatible, implantable medical device of claim 1 , wherein the base and the elongated body are integrally formed, wherein the nonpermeable coating is over a remaining portion of the external surface of the base.

11. The biocompatible, implantable medical device of claim 10 , wherein the external surface of the elongated body comprises an outlet surface, wherein the elongated body and an end of the cannula connect at the outlet surface, and the nonpermeable coating is over the external surface of the elongated body except for the outlet surface.

12. The biocompatible, implantable medical device of claim 11 , wherein the permeable coating is beneath the nonpermeable coating and over the external surface of the elongated body except for the outlet surface.

13. The biocompatible, implantable medical device of claim 11 , wherein additional nonpermeable coating is over an external surface of the cannula, and wherein additional permeable coating is over an external surface of the small molecule discharge bag.

14. The biocompatible, implantable medical device of claim 13 , wherein the additional permeable coating is also over the external surface of the cannula and beneath the additional nonpermeable coating.

15. The biocompatible, implantable medical device of claim 1 , wherein the base has a width larger than a width of the elongated body, and wherein the elongated body has a length larger than a length of the base.

16. The biocompatible, implantable medical device of claim 1 , wherein the anti-condensation filler is made of a nano-porous glass, and wherein at least one of the cannula or the small molecule discharge bag comprises additional nano-porous glass.

17. The biocompatible, implantable medical device of claim 1 , wherein the anti-condensation filler is made of a nano-porous glass, and wherein at least one of the cannula or the small molecule discharge bag comprises perfluorocarbon.

18. A method of manufacturing a biocompatible, implantable medical device, the method comprising:
spreading uncured, biocompatible silicone on a first half mold;
placing a nano-porous glass in a first portion of the first half mold, the nano-porous glass comprising a base and an elongated body extending from the base, the nano-porous glass hydrophobized based on silanization;
partially curing the uncured, biocompatible silicone on the first half mold that contains the nano-porous glass;
aligning a partially cured second half mold with the partially cured first half mold that contains the nano-porous glass;
further curing the partially cured second half mold and the partially cured first half mold to create an integrally formed workpiece that contains the nano-porous glass, a sac, and a cannula that connects the nano-porous glass and the sac;
masking a first portion and a second portion of the workpiece, the first portion corresponding to at least the base of the nano-porous glass, and the second portion corresponding to the sac; and
depositing parylene on the workpiece.

19. A method of surgically implanting a biocompatible, implantable medical device, the method comprising:
obtaining the biocompatible, implantable medical device, the biocompatible, implantable medical device comprising:
a collection and transport element comprising an anti-condensation filler, a permeable coating, and a nonpermeable coating, wherein:
the anti-condensation filler is permeable to a predetermined class of small molecules and comprises a base and an elongated body extending from the base,
the permeable coating is permeable to the small molecules and is over at least a portion of an external surface of the base,
the nonpermeable coating is nonpermeable to the small molecules and is over at least a portion of an external surface of the elongated body;

a cannula comprising a lumen; and
a small molecule discharge bag comprising an interior, wherein at least a portion of the small molecule discharge bag is permeable to the small molecules;
placing the base of the anti-condensation filler in a first environment; and placing the elongated body of the anti-condensation filler in a second environment, wherein the second environment has a higher humidity relative to the first environment, and wherein a temperature differential exists between the first environment and the second environment.

20. The method of claim 19 , wherein the base is placed between a conjunctiva and sclera of an eyeball, and wherein the elongated body is placed inside the eyeball.

Assignees

• California Inst Of Techn

Inventors

• Tai Yu-Chong
• Scianmarello Nicholas
• Cook Colin A

Classifications

• A61F9/0017 Primary

  implantable in, or in contact with, the eye, e.g. ocular inserts · CPC title

• B29K2083/005

  LSR, i.e. liquid silicone rubbers, or derivatives thereof · CPC title

• A61F2240/001

  Designing or manufacturing processes · CPC title

• A61F2250/0068

  the pharmaceutical product being in a reservoir · CPC title

• B29L2031/7548

  Cannulas · CPC title