Antibodies specific for hyperphosphorylated tau and methods of use thereof
US-10196439-B2 · Feb 5, 2019 · US
Antibodies specific for hyperphosphorylated tau and methods of use thereof
US10487142B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10487142-B2 |
| Application number | US-201916371867-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 1, 2019 |
| Priority date | Jul 12, 2016 |
| Publication date | Nov 26, 2019 |
| Grant date | Nov 26, 2019 |
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- Title
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Abstract
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The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.
First claim
Opening claim text (preview).
What is claimed is: 1. A monoclonal antibody, or an epitope binding fragment thereof, comprising: (a) a Light Chain CDR1 having the amino acid sequence of SEQ ID NO:3; (b) a Light Chain CDR2 having the amino acid sequence of SEQ ID NO:4; (c) a Light Chain CDR3 having the amino acid sequence of SEQ ID NO:5; (d) a Heavy Chain CDR1 having the amino acid sequence of SEQ ID NO:6; (e) a Heavy Chain CDR2 having the amino acid sequence of SEQ ID NO:7; and (f) a Heavy Chain CDR3 having the amino acid sequence of SEQ ID NO:39. 2. The monoclonal antibody, or epitope binding fragment thereof, according to claim 1 , comprising: (a) a Light Chain comprising the amino acid sequence of SEQ ID NO:12; and (b) a Heavy Chain comprising the amino acid sequence of SEQ ID NO:24. 3. A pharmaceutical composition comprising the monoclonal antibody, or epitope-binding fragment thereof, according to claim 1 and a pharmaceutical acceptable carrier.
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Antineoplastic agents · CPC title
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title
Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia · CPC title
- A61P25/16Primary
Anti-Parkinson drugs · CPC title
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- What does patent US10487142B2 cover?
- The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.
- Who is the assignee on this patent?
- H Lundbeck As
- What technology area does this patent fall under?
- Primary CPC classification A61P25/16. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 26 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 4 related publications on this page (citations in our corpus or others sharing the same primary CPC).