Peptide having activity to improve skin condition and use thereof

Patent metadata

Field	Value
Publication number	US-10487113-B2
Application number	US-201816046385-A
Country	US
Kind code	B2
Filing date	Jul 26, 2018
Priority date	Dec 5, 2014
Publication date	Nov 26, 2019
Grant date	Nov 26, 2019

Abstract

A peptide having activity to improve skin condition is described. The peptide exhibits a very excellent effect in improving skin condition by inhibiting MMP2 activity. A composition containing the peptide exhibits excellent biological activities, such as inhibiting collagen decomposition and melanosome migration, and thus can be used in wrinkle reduction, skin regeneration, skin elasticity improvement, anti-skin aging, wound regeneration, acne reduction, skin regeneration or skin whitening. The composition containing the peptide can be used as a pharmaceutical composition for preventing or treating MMP activity-related diseases and inflammation diseases.

First claim

The invention claimed is:

1. A peptide having an activity to improve skin condition, the peptide consisting of the amino acid sequence of SEQ ID NO: 1, wherein (i) the C-terminal end of the peptide is modified by the presence of an amino group or an azide group, or (ii) the N-terminal end of the peptide comprises a protecting group.

2. The peptide of claim 1 , wherein the peptide inhibits the activity of matrix metalloproteinase-2 (MMP2).

3. The peptide of claim 1 , wherein the peptide inhibits collagen degradation.

4. The peptide of claim 1 , wherein the peptide inhibits melanosome transfer.

5. The peptide of claim 1 , wherein the improving of the skin condition is wrinkle relief, skin regeneration, skin elasticity improvement, skin aging inhibition, wound tissue regeneration, acne relief, or skin whitening.

6. The peptide of claim 1 , wherein the C-terminal end of the peptide is modified by the presence of an amino group or an azide group.

7. The peptide of claim 1 , wherein the N-terminal end of the peptide comprises a protecting group.

8. The peptide of claim 7 , wherein the protecting group is selected from the group consisting of an acetyl group, a fluorenyl methoxy carbonyl group, a formyl group, a palmitoyl group, a myristyl group, a stearyl group, and polyethylene glycol (PEG).

9. A method for improving skin condition, the method comprising administering to a subject the peptide of claim 1 .

10. The method of claim 9 , wherein the improving of the skin condition is selected from the group consisting of wrinkle relief, skin regeneration, skin elasticity improvement, skin aging inhibition, wound tissue regeneration, acne relief, and skin whitening.

11. A method for treating a skin inflammatory disease, the method comprising administering to a subject the peptide of claim 1 .

12. The method of claim 11 , wherein the skin inflammatory disease is selected from the group consisting of eczema, psoriasis, psoriatic arthritis, atopic dermatitis, acne, allergic dermatitis, and seborrheic dermatitis.

Assignees

• Caregen Co Ltd

Inventors

• Chung Yong Ji
• Kim Eun Mi

Classifications

• A61Q19/08

  Anti-ageing preparations · CPC title

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title

• A61Q19/00

  Preparations for care of the skin · CPC title

• A61K8/64

  Proteins; Peptides; Derivatives or degradation products thereof · CPC title

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title