Drug eluting insert for implantable body

Patent metadata

Field	Value
Publication number	US-10485904-B2
Application number	US-201615240210-A
Country	US
Kind code	B2
Filing date	Aug 18, 2016
Priority date	Feb 16, 2012
Publication date	Nov 26, 2019
Grant date	Nov 26, 2019

Abstract

The present application discloses embodiments related to an implant and a method of forming an implant configured to treat a fractured bone. The implant can include a body having a proximal end, a distal end, and an outer surface extending from the proximal end to the distal end, wherein the body defines a central axis extending from the proximal end to the distal end; and a high tensile strand positioned adjacent the body such that at least a portion of the strand extends at least partially along the outer surface of the body in a direction substantially parallel with the central axis, and wherein the strand is loaded with an active agent.

First claim

What is claimed:

1. An implant comprising:
a body having a proximal end, a distal end, and a round outer surface extending from the proximal end to the distal end and defining a substantially circular cross-section along a length of the body from the proximal end to the distal end, wherein the substantially circular cross-section defines an outer diameter of the body, wherein the body defines a central axis extending from the proximal end to the distal end and wherein the body further defines at least one aperture; and
a high tensile strand positioned adjacent the body such that at least a portion of the strand extends at least partially along the round outer surface of the body outside the outer diameter in a direction substantially parallel with the central axis, wherein the strand is at least partially disposed within an aperture of the at least one aperture, and wherein the strand is loaded with an active agent;
wherein an aperture of the at least one aperture extends from the outer surface into the body such that the aperture is angularly offset with the central axis.

2. The implant of claim 1 , wherein the strand is biodegradable.

3. The implant of claim 1 , wherein the strand further includes a coating layer.

4. The implant of claim 3 , wherein the active agent is disposed as particles within the coating layer.

5. The implant of claim 3 , wherein the active agent is dissolved within the coating layer.

6. The implant of claim 1 , wherein the active agent is dissolved within the strand.

7. The implant of claim 1 , wherein the active agent is disposed as particles within the strand.

8. The implant of claim 1 , wherein the strand includes a monofilament.

9. The implant of claim 1 , wherein the strand includes a multifilament.

10. The implant of claim 1 , wherein the strand includes at least one ribbon.

11. The implant of claim 1 , wherein the active agent includes at least one antibiotic.

12. The implant of claim 11 , wherein the at least one antibiotic includes gentamicin.

13. The implant of claim 1 , wherein strand comprises one or more strands.

14. The implant of claim 13 , wherein the one or more strands are spaced apart from one another radially outside the outer diameter of the body along the outer surface.

15. The implant of claim 1 , wherein the strand is in contact with and configured to move or slide against the outer surface of the body during implantation.

16. The implant of claim 1 , wherein an aperture of the at least one aperture is configured to receive a bone fastener.

17. The implant of claim 16 , wherein the strand is at least partially disposed in the aperture configured to receive a bone fastener.

18. The implant of claim 1 , wherein the strand is at least partially disposed within the angularly offset aperture.

19. The implant of claim 1 , wherein as the body is implanted to a bone, at least a portion of the strand is in contact with both the outer surface of the body and the bone.

20. The implant of claim 1 , wherein the body includes an inner surface that defines a cannula, and wherein the cannula extends in a direction coaxial with the central axis along at least a portion of the implant, and further wherein the strand is at least partially disposed within the cannula of the body.

21. The implant of claim 1 , wherein the body is configured as an intramedullary nail.

Assignees

• Depuy Synthes Products Inc

Inventors

• Armbruster David
• Adlon Lumme Katlin
• Chomyn Jeffrey
• Yu aaron

Classifications

• A61B17/72 Primary

  Intramedullary devices, e.g. pins or nails · CPC title

• A61F2002/30677

  Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body · CPC title

• A61L2300/406

  Antibiotics · CPC title

• A61L2430/02

  for reconstruction of bones; weight-bearing implants · CPC title

• Y10T29/49826

  Assembling or joining · CPC title