Core-satellite nanocomposites for MRI and photothermal therapy

Patent metadata

Field	Value
Publication number	US-10485886-B2
Application number	US-201815972674-A
Country	US
Kind code	B2
Filing date	May 7, 2018
Priority date	Sep 5, 2013
Publication date	Nov 26, 2019
Grant date	Nov 26, 2019

Abstract

The present invention provides methods, compositions, systems, and kits comprising core-satellite nanocomposites useful for photothermal and/or MRI applications (e.g., tumor treatment and/or imaging). In certain embodiments, the core-satellite nanocomposites comprise: i) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core, and ii) at least one satellite component attached to, or absorbed to, the biocompatible coating. In some embodiments, the nanoparticle core and satellite component are composed of near-infrared photothermal agent material and/or MRI contrast agent material. In further embodiments, the satellite component is additionally or alternatively composed of near-infrared optical dye material.

First claim

We claim:

1. A composition comprising a plurality of core-satellite nanocomposites, wherein said core-satellite nanocomposites individually comprise:
a) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core,
wherein said biocompatible coating comprises polysiloxane,
wherein said nanoparticle core comprises Fe 3 O 4 and has a diameter between 10 and 20 nm, and
b) a plurality of satellite components attached to, or absorbed to, said biocompatible coating, wherein each of said satellite components comprises a gold, or gold-sulfide, nanoparticle with a diameter between 2 and 5 nm; and
wherein said plurality of satellite components are visible as discrete nanoparticles, that are not part of a shell surrounding said core nanoparticle complex, using a transmission electron microscope (TEM).

2. The composition of claim 1 , further comprising a physiologically compatible aqueous solution.

3. The composition of claim 1 , wherein said Fe3O4 is highly crystallized and has an X-ray diffraction (XRD) pattern where the brightest diffraction ring is from the 440 plane.

4. The composition of claim 1 , wherein said nanoparticle core has a spherical shape.

5. The composition of claim 1 , wherein said nanoparticle core has a cubic shape.

Assignees

• Univ Michigan Regents

Inventors

• Chen Hongwei
• Sun Duxin

Classifications

• A61N5/062

  Photodynamic therapy, i.e. excitation of an agent · CPC title

• G01R33/4808

  Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT] · CPC title

• A61K49/1827

  having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle · CPC title

• A61K49/1824 Primary

  coated or functionalised nanoparticles (liposomes A61K49/1812; nanoemulsions A61K49/1806; micelles A61K49/1809) · CPC title

• A61B5/0035

  adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography · CPC title